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ZBTB16 and PSMD11
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ZBTB16
PSMD11
Description
zinc finger and BTB domain containing 16
proteasome 26S subunit, non-ATPase 11
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Nuclear Body
PML Body
Nuclear Speck
Transcription Repressor Complex
Protein-containing Complex
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Lid Subcomplex
Membrane
Proteasome Accessory Complex
Secretory Granule Lumen
Ficolin-1-rich Granule Lumen
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Structural Molecule Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Mesonephros Development
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Central Nervous System Development
Negative Regulation Of Cell Population Proliferation
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Protein Ubiquitination
Hemopoiesis
Myeloid Cell Differentiation
Positive Regulation Of Chondrocyte Differentiation
Protein Localization To Nucleus
Embryonic Hindlimb Morphogenesis
Forelimb Morphogenesis
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Male Germ-line Stem Cell Asymmetric Division
Positive Regulation Of NK T Cell Differentiation
Cartilage Development
Positive Regulation Of Cartilage Development
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasome Assembly
Neutrophil Degranulation
Regulation Of MRNA Stability
Post-translational Protein Modification
Stem Cell Differentiation
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Skeletal defects, genital hypoplasia, and mental retardation
Acute myeloid leukemia (AML)
GWAS
Basophil count (
32888494
)
Chronotype (
30696823
)
Conduct disorder (maternal expressed emotions interaction) (
18846501
)
Corneal astigmatism (
29422769
)
Diisocyanate-induced asthma (
25918132
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Non-glioblastoma glioma (
28346443
26424050
)
Paneth cell defects in Crohn's disease (
28352666
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Polycystic ovary syndrome (
26284813
30566500
)
Red blood cell count (
32888494
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Urinary albumin-to-creatinine ratio (
32600054
)
White blood cell count (
32888494
27863252
)
Interacting Genes
154 interacting genes:
ACP5
ADAMTS4
AGTR2
AMOTL2
ANAPC5
ANXA7
AR
ATP6AP2
ATP7B
BCL6
BLZF1
BMI1
CARD9
CASP3
CCDC130
CCDC85B
CCHCR1
CD81
CDK1
CDK4
CDKN1A
CEBPA
CEP70
CEP72
CFH
CIDEA
COG6
COQ6
CTDSP1
DLST
DNAAF5
DNM2
DPM1
EEF1A1
EFHC2
EIF2S2
ENOX1
EP300
EPN1
ERVK-6
ESR1
FAM217B
FAM90A1
FCHO1
FHL2
FHL5
FSHR
GATA1
GATA2
GCSH
GNE
GOLGA2
GOLGA6L9
GPANK1
GRB7
GSTM4
HBEGF
HDAC1
HDAC2
HDAC3
HDAC4
HDAC5
HDAC6
HDAC7
HDAC9
HDX
HOXA1
HOXC5
HSF2BP
ICAM3
IL6
KIAA1549
KIFC3
KRT40
KRTAP4-12
LAMTOR5
LDOC1
LMTK3
LRIG1
LSM2
LYAR
MAGEA11
MAP3K3
MCUB
MEOX2
MID2
MTUS2
MX1
MYLIP
NCOR1
NCOR2
NFKBID
NME4
NR3C1
OSBPL3
PAFAH1B3
PARP1
PGAM5
PHF1
PIAS2
PIBF1
PLSCR1
PMAIP1
PML
PNRC2
PRKAR1B
PSMD11
PSMD2
QTRT1
RAB27A
RAB3IP
RARA
RB1
REL
RFLNB
RINT1
RUNX1T1
RXRA
SH2D4A
SIN3A
SIN3B
SMAD3
SMN1
SP1
SPOP
SPRY2
SUMO1
TAB2
TERF1
THNSL2
TK1
TLE5
TOLLIP
TRAF1
TRAF2
TRAF4
TRIM21
TRIM23
TRIM27
TRIM54
TTC23
TXNIP
UBE2I
VDR
VTA1
WASHC1
WDR33
ZBTB32
ZBTB42
ZNF24
ZNF281
ZNF552
ZNF620
ZNF655
40 interacting genes:
APP
BRD7
CCDC90B
CCSER2
CDC42
COPS2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRKAB2
PRKACA
PRMT6
PSMC5
PSMD6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UBC
UNC119
USP4
ZBTB16
ZHX1
Entrez ID
7704
5717
HPRD ID
11762
05119
Ensembl ID
ENSG00000109906
ENSG00000108671
Uniprot IDs
A0A024R3C6
Q05516
O00231
PDB IDs
1BUO
1CS3
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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