ZBTB16 and FSHR

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZBTB16	FSHR
Description		zinc finger and BTB domain containing 16	follicle stimulating hormone receptor
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcription Repressor Complex Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Follicle-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesonephros Development Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin Corifollitropin alfa
Diseases		Skeletal defects, genital hypoplasia, and mental retardation Acute myeloid leukemia (AML)	Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Ovarian hyperstimulation syndrome (OHSS)
GWAS		Basophil count ( 32888494) Chronotype ( 30696823) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Corneal astigmatism ( 29422769) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443 26424050) Paneth cell defects in Crohn's disease ( 28352666) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Polycystic ovary syndrome ( 26284813 30566500) Red blood cell count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urinary albumin-to-creatinine ratio ( 32600054) White blood cell count ( 32888494 27863252)	Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Erectile dysfunction and prostate cancer treatment ( 20932654) Laterality in neovascular age-related macular degeneration ( 28775256) Lean body mass ( 28552196) Low density lipoprotein cholesterol levels ( 30498476) Lung cancer in ever smokers ( 28604730) Metabolite levels ( 23823483) Morning person ( 30696823) Plasma anti-thyroglobulin levels ( 29678681) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		154 interacting genes: ACP5 ADAMTS4 AGTR2 AMOTL2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BLZF1 BMI1 CARD9 CASP3 CCDC130 CCDC85B CCHCR1 CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COG6 COQ6 CTDSP1 DLST DNAAF5 DNM2 DPM1 EEF1A1 EFHC2 EIF2S2 ENOX1 EP300 EPN1 ERVK-6 ESR1 FAM217B FAM90A1 FCHO1 FHL2 FHL5 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GOLGA6L9 GPANK1 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX HOXA1 HOXC5 HSF2BP ICAM3 IL6 KIAA1549 KIFC3 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LRIG1 LSM2 LYAR MAGEA11 MAP3K3 MCUB MEOX2 MID2 MTUS2 MX1 MYLIP NCOR1 NCOR2 NFKBID NME4 NR3C1 OSBPL3 PAFAH1B3 PARP1 PGAM5 PHF1 PIAS2 PIBF1 PLSCR1 PMAIP1 PML PNRC2 PRKAR1B PSMD11 PSMD2 QTRT1 RAB27A RAB3IP RARA RB1 REL RFLNB RINT1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TLE5 TOLLIP TRAF1 TRAF2 TRAF4 TRIM21 TRIM23 TRIM27 TRIM54 TTC23 TXNIP UBE2I VDR VTA1 WASHC1 WDR33 ZBTB32 ZBTB42 ZNF24 ZNF281 ZNF552 ZNF620 ZNF655	20 interacting genes: AKT2 APPL1 ARR3 CANX CBX5 CGA FSHB GRK2 GRK4 GRK6 MT-RNR2 RPS27A S100A10 TOP1 TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		7704	2492
HPRD ID		11762	00639
Ensembl ID		ENSG00000109906	ENSG00000170820
Uniprot IDs		A0A024R3C6 Q05516	A0A1D5RMN4 P23945
PDB IDs		1BUO 1CS3	1XUN 1XWD 4AY9 4MQW
Enriched GO Terms of Interacting Partners?
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