SPOP and CHAF1A

Data Source:
BioGRID (two hybrid)

		SPOP	CHAF1A
Description		speckle type BTB/POZ protein	chromatin assembly factor 1 subunit A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Chromatin Nucleus Protein-containing Complex CAF-1 Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Chromatin Binding Protein Binding Identical Protein Binding Unfolded Protein Binding Chromo Shadow Domain Binding
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	DNA Replication DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Cell Cycle Chromatin Assembly
Pathways		Hedgehog 'on' state
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		66 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	47 interacting genes: ANP32A ANP32B ASF1A ASF1B BLM CBX1 CBX5 CDC7 CDK2 CHAF1B CREBBP DBF4 DDX41 H3-4 H3C6 HMGB2 LZTR1 MBD1 MEI4 MSH6 NOTO PABPC1 PAX6 PCBD2 PCNA POU6F2 RBFOX2 REL SERTAD1 SET SPOP STAT5B SUMO1 SUMO2 SUMO3 TCERG1 TCF4 TRIB3 TRIM28 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAQ ZNF408 ZNF620
Entrez ID		8405	10036
HPRD ID		16004	03148
Ensembl ID		ENSG00000121067	ENSG00000167670
Uniprot IDs		O43791	Q13111
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A
Enriched GO Terms of Interacting Partners?
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