ZBTB16 and HDAC7

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ZBTB16	HDAC7
Description		zinc finger and BTB domain containing 16	histone deacetylase 7
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcription Repressor Complex Protein-containing Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Metal Ion Binding Repressing Transcription Factor Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesonephros Development Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development	Protein Deacetylation Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Trichostatin A Belinostat Panobinostat
Diseases		Skeletal defects, genital hypoplasia, and mental retardation Acute myeloid leukemia (AML)
GWAS		Basophil count ( 32888494) Chronotype ( 30696823) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Corneal astigmatism ( 29422769) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443 26424050) Paneth cell defects in Crohn's disease ( 28352666) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Polycystic ovary syndrome ( 26284813 30566500) Red blood cell count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urinary albumin-to-creatinine ratio ( 32600054) White blood cell count ( 32888494 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 32296059) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) White blood cell count ( 32888494)
Interacting Genes		154 interacting genes: ACP5 ADAMTS4 AGTR2 AMOTL2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BLZF1 BMI1 CARD9 CASP3 CCDC130 CCDC85B CCHCR1 CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COG6 COQ6 CTDSP1 DLST DNAAF5 DNM2 DPM1 EEF1A1 EFHC2 EIF2S2 ENOX1 EP300 EPN1 ERVK-6 ESR1 FAM217B FAM90A1 FCHO1 FHL2 FHL5 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GOLGA6L9 GPANK1 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX HOXA1 HOXC5 HSF2BP ICAM3 IL6 KIAA1549 KIFC3 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LRIG1 LSM2 LYAR MAGEA11 MAP3K3 MCUB MEOX2 MID2 MTUS2 MX1 MYLIP NCOR1 NCOR2 NFKBID NME4 NR3C1 OSBPL3 PAFAH1B3 PARP1 PGAM5 PHF1 PIAS2 PIBF1 PLSCR1 PMAIP1 PML PNRC2 PRKAR1B PSMD11 PSMD2 QTRT1 RAB27A RAB3IP RARA RB1 REL RFLNB RINT1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TLE5 TOLLIP TRAF1 TRAF2 TRAF4 TRIM21 TRIM23 TRIM27 TRIM54 TTC23 TXNIP UBE2I VDR VTA1 WASHC1 WDR33 ZBTB32 ZBTB42 ZNF24 ZNF281 ZNF552 ZNF620 ZNF655	59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRBA2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 SOGA1 TIAF1 UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16
Entrez ID		7704	51564
HPRD ID		11762	09133
Ensembl ID		ENSG00000109906	ENSG00000061273
Uniprot IDs		A0A024R3C6 Q05516	Q8WUI4
PDB IDs		1BUO 1CS3	3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?
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