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CATSPER1 and EFEMP2
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
CATSPER1
EFEMP2
Description
cation channel sperm associated 1
EGF containing fibulin extracellular matrix protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Motile Cilium
CatSper Complex
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Molecular Function
Calcium Activated Cation Channel Activity
Voltage-gated Calcium Channel Activity
Protein Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Biological Process
Calcium Ion Transport
Multicellular Organism Development
Spermatogenesis
Cell Differentiation
Flagellated Sperm Motility
Response To Progesterone
Regulation Of Ion Transmembrane Transport
Sperm-egg Recognition
Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Calcium Ion Transmembrane Transport
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways
Sperm Motility And Taxes
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Acne (severe) (
24927181
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
31562340
)
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Retinal detachment or retinal break (
31816047
)
Interacting Genes
116 interacting genes:
ABLIM3
ADAMTSL4
AGR2
AGR3
AJUBA
AKAP8L
APOA2
ARID5A
BEGAIN
C11orf1
C11orf16
C9orf24
CARD10
CDPF1
CHIC2
CHRD
CPSF7
CTBP2
CYSRT1
EFEMP2
EMD
EYA2
FHL5
FRS3
FST
GLI1
HNRNPH1
HOXA1
IKZF3
KHDRBS2
KPRP
KRT31
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP17-1
KRTAP19-5
KRTAP19-6
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP3-2
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-7
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LASP1
LCE1D
LCE1E
LCE1F
LCE2C
LIMS1
LZTS2
MDFI
MTUS2
MYCL
NBPF19
NOTCH2NLA
PAK5
PDLIM7
PLA2G10
PLAGL2
PLSCR1
PLSCR3
PMF1-BGLAP
PPP1R32
PTPN21
RFX6
RGS19
RGS20
RIMBP3
RSPO2
SCRG1
SIVA1
SORBS3
SPRY2
SPRY3
SSC4D
TGFB1
TNS2
TRAF2
TRIM27
TRIM42
TRIM8
TRIP6
TSPAN4
VWC2
ZBTB42
ZIM2
ZNF688
ZNF774
ZNF837
130 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
Entrez ID
117144
30008
HPRD ID
09396
05221
Ensembl ID
ENSG00000175294
ENSG00000172638
Uniprot IDs
Q8NEC5
A0A024R5G1
O95967
Q9H3D5
PDB IDs
2KL7
Enriched GO Terms of Interacting Partners
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