JAM3 and RHOU

Data Source:
BioGRID (pull down)

		JAM3	RHOU
Description		junctional adhesion molecule 3	ras homolog family member U
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Protein Complex Involved In Cell Adhesion	Golgi Membrane Podosome Cytosol Plasma Membrane Focal Adhesion Cell Projection
	Molecular Function	Integrin Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity	GTPase Activity Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Cellular Extravasation Cell-matrix Adhesion Spermatid Development Transmission Of Nerve Impulse Establishment Of Cell Polarity Extracellular Matrix Organization Axon Regeneration Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability	Endocytosis Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Cytokine-mediated Signaling Pathway Cell Projection Assembly Cdc42 Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions	Rho GTPase cycle Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Neutrophil count ( 32888494)	Aging ( 22773346) Basal cell carcinoma ( 24403052 25855136 27539887 18849993) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1	128 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 ARNTL AS3MT ATP5MG ATP6AP1 BDNF BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A ESYT1 FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 MARCKS ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIV2L SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		83700	58480
HPRD ID		06042	06965
Ensembl ID		ENSG00000166086	ENSG00000116574
Uniprot IDs		Q9BX67	A0A024R3Q7 Q7L0Q8
PDB IDs			2Q3H
Enriched GO Terms of Interacting Partners?
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