JAM3 and ITGAX

Data Source:
HPRD (in vivo)

		JAM3	ITGAX
Description		junctional adhesion molecule 3	integrin subunit alpha X
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Protein Complex Involved In Cell Adhesion	Plasma Membrane Integrin Complex Cell Surface Membrane Secretory Granule Membrane Integrin AlphaX-beta2 Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Integrin Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity	Integrin Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Cellular Extravasation Cell-matrix Adhesion Spermatid Development Transmission Of Nerve Impulse Establishment Of Cell Polarity Extracellular Matrix Organization Axon Regeneration Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability	Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Myelination Heterotypic Cell-cell Adhesion Neutrophil Degranulation Positive Regulation Of Angiogenesis Leukocyte Migration Positive Regulation Of Endothelial Tube Morphogenesis
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions	Cell surface interactions at the vascular wall Integrin cell surface interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs			Efalizumab
Diseases
GWAS		Blood protein levels ( 30072576) Neutrophil count ( 32888494)	IgA nephropathy ( 25305756) Post bronchodilator FEV1 ( 26634245) Systemic lupus erythematosus ( 18204098)
Interacting Genes		8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1	5 interacting genes: C3 FCER2 ITGB2 JAM3 MIA3
Entrez ID		83700	3687
HPRD ID		06042	01051
Ensembl ID		ENSG00000166086	ENSG00000140678
Uniprot IDs		Q9BX67	H3BN02 P20702
PDB IDs			1N3Y 2LUV 3K6S 3K71 3K72 4NEH 4NEN 5ES4
Enriched GO Terms of Interacting Partners?
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