JAM3 and JAM2

Data Source:
HPRD (in vivo, in vitro)

		JAM3	JAM2
Description		junctional adhesion molecule 3	junctional adhesion molecule 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Protein Complex Involved In Cell Adhesion	Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Cell Surface Somatodendritic Compartment Cell-cell Contact Zone Tight Junction Protein Complex Involved In Cell Adhesion
	Molecular Function	Integrin Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity	Integrin Binding Protein Binding
	Biological Process	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Cellular Extravasation Cell-matrix Adhesion Spermatid Development Transmission Of Nerve Impulse Establishment Of Cell Polarity Extracellular Matrix Organization Axon Regeneration Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability	Spermatid Development Myoblast Fusion Extracellular Matrix Organization Negative Regulation Of Myelination Maintenance Of Blood-brain Barrier Cellular Extravasation Leukocyte Migration Leukocyte Tethering Or Rolling Lymphocyte Aggregation Hematopoietic Stem Cell Migration To Bone Marrow Cell-cell Adhesion Positive Regulation Of Lymphocyte Migration
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions	Cell surface interactions at the vascular wall Integrin cell surface interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Neutrophil count ( 32888494)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive performance ( 19734545) Longitudinal change in brain amyloid plaque burden ( 26268530) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1	9 interacting genes: CSNK1A1L F2RL2 GPR20 JAM3 NME3 SOX8 TDP2 TJP1 YBX1
Entrez ID		83700	58494
HPRD ID		06042	06041
Ensembl ID		ENSG00000166086	ENSG00000154721
Uniprot IDs		Q9BX67	P57087
PDB IDs
Enriched GO Terms of Interacting Partners?
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