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RHOU and POT1
Data Source:
BioGRID
(pull down)
RHOU
POT1
Description
ras homolog family member U
protection of telomeres 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Podosome
Cytosol
Plasma Membrane
Focal Adhesion
Cell Projection
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleoplasm
Shelterin Complex
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Metal Ion Binding
Protein Binding
Telomerase Inhibitor Activity
DEAD/H-box RNA Helicase Binding
Telomeric DNA Binding
Single-stranded Telomeric DNA Binding
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
G-rich Strand Telomeric DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
G-rich Single-stranded DNA Binding
Biological Process
Endocytosis
Cytoskeleton Organization
Regulation Of Cell Shape
Cell Migration
Cytokine-mediated Signaling Pathway
Cell Projection Assembly
Cdc42 Protein Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Targeting To Mitochondrion
Telomere Maintenance Via Telomerase
Telomere Capping
Telomere Assembly
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Duplex Unwinding
Positive Regulation Of Helicase Activity
Positive Regulation Of Telomerase Activity
Negative Regulation Of Telomerase Activity
Positive Regulation Of DNA Strand Elongation
Telomeric D-loop Disassembly
Establishment Of Protein Localization To Telomere
Regulation Of DNA Helicase Activity
Positive Regulation Of DNA Helicase Activity
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Rho GTPase cycle
Interleukin-4 and Interleukin-13 signaling
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Aging (
22773346
)
Basal cell carcinoma (
24403052
25855136
27539887
18849993
)
Chronic lymphocytic leukemia (
28165464
)
Dental caries (
23259602
)
Endometriosis (
20844546
)
Leukoderma in response to rhododendrol (
32558222
)
Mercury levels (
26025379
)
Non-melanoma skin cancer (
29739929
)
Response to antidepressants in depression (
27622933
)
Type 2 diabetes (
23300278
)
Chronic lymphocytic leukemia (
28165464
24292274
)
Cutaneous malignant melanoma (
26237428
)
Leukocyte telomere length (
32109421
31171785
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Interacting Genes
128 interacting genes:
ACAD8
ADM2
ALG13
ANGPT4
ANXA4
ANXA6
AP1S1
ARHGEF25
ARNTL
AS3MT
ATP5MG
ATP6AP1
BDNF
BNIPL
BRF1
BRINP3
C14orf119
CDKL4
CFAP100
CHRNA4
CLEC7A
CPNE3
CTCF
CUL5
DACT2
DMRT2
DNM2
DOK4
DSCR8
EIF4B
ELP5
EMC2
ERF
ERO1A
ESYT1
FAM110B
FCHO2
FKBP15
GALNTL5
GLI3
GPRIN2
GRB2
H2BC14
HCAR1
HINT3
HSD17B13
ID2
IFFO1
IL17F
INSM2
JAM3
KAAG1
KIAA1191
KLRC3
LANCL2
LARS2
LAYN
LMO7
LYL1
MARCKS
ME3
MOS
MRAS
MRPL15
NCK1
NCR1
NPM3
NR1H2
NRBF2
NXPH4
OXCT2
P4HTM
PAK1
PAK4
PCDHGA4
PDLIM3
PGK1
PIP5K1A
PLCG1
PLEK
PLOD3
POT1
PRB1
PRPF18
PSMA4
PXN
QTRT1
RAB40A
RAD51D
RALBP1
RASSF1
RBIS
RPL23AP5
RPS15A
RPS17P16
S100A4
SEC14L4
SEMA3G
SEPTIN6
SIVA1
SKIV2L
SLC26A1
SNU13
SOX4
SSC4D
STX16
SYK
TCN2
TEKT2
TMEM106A
TMEM169
TMEM255B
TRIM59
USP37
UTP3
VWA5A
WNT6
XPA
ZFAND2B
ZFP64
ZKSCAN7
ZNF117
ZNF177
ZNF20
ZNF569
ZNF625
ZNF747
ZNF84
166 interacting genes:
ACD
ACOT7
ACTB
ACTN4
ACY1
AFAP1L2
AHCY
AHNAK
AIPL1
ALDH1A1
ALDH3A1
AMPD2
ANKMY2
ANXA2
ANXA4
APPL2
ARHGDIA
ARID3B
ARRB1
BAG3
BCAS2
BIN2
C2orf74
CALD1
CAMK1D
CCDC32
CCDC9
CCM2
CFL1
CFL2
CKB
CLIC3
CNST
CORO1A
COX6A2
CPNE3
CPPED1
CRK
CRYGS
CSNK2B
CYP4F11
DBN1
DBNL
DCX
DDX19B
DNPH1
DOK2
DPP3
DPYSL3
ECI1
EEF1D
EIF3G
EIF4B
ENO2
ENSA
EPB41L1
EVL
FAM131B
FBP1
FES
GAMT
GAPDH
GAS2L1
GFPT2
GNMT
GPA33
GPR52
GRN
H2AC20
HAAO
HLCS
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA1A
IFRD2
IL1RN
ISYNA1
IVL
KHDRBS1
KIAA1191
KRT18
LAMC3
LASP1
LDHA
LDHB
MADD
MAGEA4
MAP4
MAP4K2
MAP7
MDM2
MICA
MT1X
MVK
MVP
MYO5C
NAP1L1
NCDN
NOL3
NUDC
NUDCD2
NXNL1
PACSIN1
PACSIN2
PAGE2
PAGE5
PAK4
PALM
PCP4
PDE1B
PDLIM2
PEX5
PFKP
PGLS
PGM1
PGM2
PHYHD1
PHYKPL
PIPOX
PRMT7
PROSER2
PYM1
RBKS
RECQL4
RGS14
RHOU
RIF1
RPAP1
RPSA
RTN4
SARS1
SBDS
SERTAD1
SH3BP1
SNCG
STIP1
STUB1
SULT1B1
SULT1C2
SULT4A1
SYAP1
TAGLN
TBCD
TERF1
TMSB10
TMSB4Y
TNKS
TOMM34
TPI1
TPP1
TRIM16
TRIP10
TUBB2A
TUBB4B
TWF2
WIPI2
XAGE2
YWHAE
YWHAG
ZBED2
ZBTB49
ZFP36L1
ZNF32
ZNF790
Entrez ID
58480
25913
HPRD ID
06965
07572
Ensembl ID
ENSG00000116574
ENSG00000128513
Uniprot IDs
A0A024R3Q7
Q7L0Q8
A0A024R739
A8MTK3
Q5MJ33
Q9NUX5
PDB IDs
2Q3H
1XJV
3KJO
3KJP
5H65
5UN7
Enriched GO Terms of Interacting Partners
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