Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
RHOU and SYK
Data Source:
BioGRID
(pull down)
RHOU
SYK
Description
ras homolog family member U
spleen associated tyrosine kinase
Image
GO Annotations
Cellular Component
Golgi Membrane
Podosome
Cytosol
Plasma Membrane
Focal Adhesion
Cell Projection
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
B Cell Receptor Complex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Early Phagosome
Protein-containing Complex
T Cell Receptor Complex
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Metal Ion Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Interleukin-15 Receptor Binding
Protein Kinase Binding
Phosphatase Binding
Toll-like Receptor Binding
SH2 Domain Binding
Biological Process
Endocytosis
Cytoskeleton Organization
Regulation Of Cell Shape
Cell Migration
Cytokine-mediated Signaling Pathway
Cell Projection Assembly
Cdc42 Protein Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Targeting To Mitochondrion
Angiogenesis
Lymph Vessel Development
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Macrophage Activation Involved In Immune Response
Neutrophil Activation Involved In Immune Response
Leukocyte Activation Involved In Immune Response
Serotonin Secretion By Platelet
Protein Phosphorylation
Protein Import Into Nucleus
Leukocyte Cell-cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Activation Of JUN Kinase Activity
Animal Organ Morphogenesis
Regulation Of Platelet Activation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Leukotriene Biosynthetic Process
Cell Differentiation
Platelet Activation
Neutrophil Chemotaxis
Positive Regulation Of Protein-containing Complex Assembly
Receptor Internalization
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-3 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Superoxide Anion Generation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Interleukin-2-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Mast Cell Degranulation
Regulation Of Neutrophil Degranulation
Beta Selection
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Bone Resorption
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Blood Vessel Morphogenesis
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
B Cell Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Killing Of Cells Of Other Organism
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Molecule Of Fungal Origin
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Arachidonic Acid Secretion
Regulation Of Platelet Aggregation
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Rho GTPase cycle
Interleukin-4 and Interleukin-13 signaling
GPVI-mediated activation cascade
GPVI-mediated activation cascade
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Integrin signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Interleukin-2 signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Staurosporine
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
Tamatinib
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
Ellagic acid
Fostamatinib
Diseases
GWAS
Aging (
22773346
)
Basal cell carcinoma (
24403052
25855136
27539887
18849993
)
Chronic lymphocytic leukemia (
28165464
)
Dental caries (
23259602
)
Endometriosis (
20844546
)
Leukoderma in response to rhododendrol (
32558222
)
Mercury levels (
26025379
)
Non-melanoma skin cancer (
29739929
)
Response to antidepressants in depression (
27622933
)
Type 2 diabetes (
23300278
)
Alzheimer's disease (
30636644
)
Anti-saccade response (
29064472
)
Atrial fibrillation (
28416822
)
Chromosomal aberration frequency (total) (
31586183
)
Frontal pole volume (
31530798
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Multiple sclerosis (
21833088
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Type 2 diabetes (
22456796
)
Vascular dementia (
23480133
)
Interacting Genes
128 interacting genes:
ACAD8
ADM2
ALG13
ANGPT4
ANXA4
ANXA6
AP1S1
ARHGEF25
ARNTL
AS3MT
ATP5MG
ATP6AP1
BDNF
BNIPL
BRF1
BRINP3
C14orf119
CDKL4
CFAP100
CHRNA4
CLEC7A
CPNE3
CTCF
CUL5
DACT2
DMRT2
DNM2
DOK4
DSCR8
EIF4B
ELP5
EMC2
ERF
ERO1A
ESYT1
FAM110B
FCHO2
FKBP15
GALNTL5
GLI3
GPRIN2
GRB2
H2BC14
HCAR1
HINT3
HSD17B13
ID2
IFFO1
IL17F
INSM2
JAM3
KAAG1
KIAA1191
KLRC3
LANCL2
LARS2
LAYN
LMO7
LYL1
MARCKS
ME3
MOS
MRAS
MRPL15
NCK1
NCR1
NPM3
NR1H2
NRBF2
NXPH4
OXCT2
P4HTM
PAK1
PAK4
PCDHGA4
PDLIM3
PGK1
PIP5K1A
PLCG1
PLEK
PLOD3
POT1
PRB1
PRPF18
PSMA4
PXN
QTRT1
RAB40A
RAD51D
RALBP1
RASSF1
RBIS
RPL23AP5
RPS15A
RPS17P16
S100A4
SEC14L4
SEMA3G
SEPTIN6
SIVA1
SKIV2L
SLC26A1
SNU13
SOX4
SSC4D
STX16
SYK
TCN2
TEKT2
TMEM106A
TMEM169
TMEM255B
TRIM59
USP37
UTP3
VWA5A
WNT6
XPA
ZFAND2B
ZFP64
ZKSCAN7
ZNF117
ZNF177
ZNF20
ZNF569
ZNF625
ZNF747
ZNF84
107 interacting genes:
APP
AR
BLNK
BTK
CALM1
CBL
CBLB
CD19
CD22
CD3E
CD72
CD79A
CD79B
COASY
CRKL
CSF2RB
CSF3R
CTTN
DBNL
DPP9
DUSP3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
FCER1G
FCGR1A
FCGR2A
FCGR3A
FCRL3
FGR
FYN
GAB1
GAB2
GRB2
HCLS1
HDAC1
HDAC2
HDAC3
HDAC4
HDAC6
HDAC9
HGS
HNRNPU
IL15RA
IL2RB
ITGB2
JAK1
KIT
LAT
LAX1
LCK
LCP2
LYN
MAP4K1
MAPK3
MAPT
MET
MS4A2
NEDD4
NFAM1
PAG1
PIK3AP1
PIK3R1
PIK3R2
PLCG1
PLCG2
POU2AF1
PRKCA
PRKD1
PTK2
PTK2B
PTPN6
PXN
RASA1
RHOU
RPS10
RPS6KA1
RPS6KB1
RPS6KB2
SELPLG
SH2B2
SH2D2A
SH3BP2
SHC1
SIT1
SLA
SLC4A1
SNCA
SRC
STAT1
STAT3
STAT5A
TERF1
TLR4
TNFRSF1A
TRAF6
TRIM15
TUBA1A
TUBA4A
TYROBP
UBASH3B
UBB
USP25
VAV1
VAV2
Entrez ID
58480
6850
HPRD ID
06965
02514
Ensembl ID
ENSG00000116574
ENSG00000165025
Uniprot IDs
A0A024R3Q7
Q7L0Q8
A0A024R244
A0A024R273
P43405
PDB IDs
2Q3H
1A81
1CSY
1CSZ
1XBA
1XBB
1XBC
3BUW
3EMG
3FQE
3FQH
3FQS
3SRV
3TUB
3TUC
3TUD
3VF8
3VF9
4DFL
4DFN
4F4P
4FL1
4FL2
4FL3
4FYN
4FYO
4FZ6
4FZ7
4GFG
4I0R
4I0S
4I0T
4PUZ
4PV0
4PX6
4RSS
4RX7
4RX8
4RX9
4WNM
4XG2
4XG3
4XG4
4XG6
4XG7
4XG8
4XG9
4YJO
4YJP
4YJQ
4YJR
4YJS
4YJT
4YJU
4YJV
5C26
5C27
5CXH
5CXZ
5CY3
5GHV
5LMA
5LMB
5T68
5TIU
5TR6
5TT7
5Y5T
5Y5U
6HM6
6HM7
6SSB
6VOV
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?