MED25 and PLEKHB2

Data Source:
BioGRID (two hybrid)

		MED25	PLEKHB2
Description		mediator complex subunit 25	pleckstrin homology domain containing B2
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GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Mediator Complex	Integral Component Of Membrane Recycling Endosome Membrane
	Molecular Function	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly	Regulation Of Cell Differentiation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood trace element (Se levels) ( 23720494)
Interacting Genes		37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2	49 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A
Entrez ID		81857	55041
HPRD ID		14380	15144
Ensembl ID		ENSG00000104973	ENSG00000115762
Uniprot IDs		Q71SY5	A0A024QZ35 A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7
PDB IDs		2KY6 2L23 2L6U 2XNF	3AJ4 3VIA
Enriched GO Terms of Interacting Partners?
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