MED25 and TFG

Data Source:
BioGRID (two hybrid)

		MED25	TFG
Description		mediator complex subunit 25	trafficking from ER to golgi regulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Mediator Complex	Golgi Membrane Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Endoplasmic Reticulum Exit Site
	Molecular Function	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling COPII Vesicle Coating
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	COPII-mediated vesicle transport
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Non-small cell lung cancer Thyroid cancer
GWAS		Blood trace element (Se levels) ( 23720494)	Refractive error ( 32231278)
Interacting Genes		37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2	73 interacting genes: ANXA11 ARHGEF16 ARL15 BOLL BPIFA1 C19orf54 CEP126 CEP55 CRMP1 CRX CSTF2 DAZAP2 DVL3 ERG28 EWSR1 EYA2 FAM168A FOXH1 GBP2 GPRASP1 GRB2 HGS HNRNPF INCA1 INTS11 KHDC1 KRTAP26-1 LASP1 LENG8 MAGED1 MAPK1IP1L MED21 MED25 METTL27 MSS51 MYOT NADSYN1 NID2 OXER1 PEF1 PFDN5 PIN1 PLA2G10 PLEKHG4 PLSCR1 POU2AF1 PPP1R32 PRR20A PRR20B PRR20C PRR20D PRR20E PTPN6 RBPMS RIPPLY2 RNF4 SEC24A SF3A2 SF3B4 SMUG1 SPG21 STAT5B STH TBX19 TEX37 TRIM25 TSSK2 UBAP2 UBE2I VPS37C WWOX ZMYM5 ZNF34
Entrez ID		81857	10342
HPRD ID		14380	03932
Ensembl ID		ENSG00000104973	ENSG00000114354
Uniprot IDs		Q71SY5	Q05BK6 Q92734
PDB IDs		2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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