EME1 and SLX1A

Data Source:
BioGRID (pull down)

		EME1	SLX1A
Description		essential meiotic structure-specific endonuclease 1	SLX1 homolog A, structure-specific endonuclease subunit
Image			No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleoplasm Nucleolus Holliday Junction Resolvase Complex	Nucleoplasm Slx1-Slx4 Complex
	Molecular Function	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Interstrand Cross-link Repair Telomeric D-loop Disassembly Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2	6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		146956	548593
HPRD ID		10937	18681
Ensembl ID		ENSG00000154920	ENSG00000132207
Uniprot IDs		Q96AY2	Q9BQ83
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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