EME1 and MUS81

Data Source:
HPRD (in vitro)

		EME1	MUS81
Description		essential meiotic structure-specific endonuclease 1	MUS81 structure-specific endonuclease subunit
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GO Annotations	Cellular Component	Heterochromatin Nucleoplasm Nucleolus Holliday Junction Resolvase Complex	Nucleus Nucleoplasm Nucleolus Holliday Junction Resolvase Complex
	Molecular Function	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Break-induced Replication DNA Catabolic Process, Endonucleolytic DNA Repair Intra-S DNA Damage Checkpoint Osteoblast Proliferation Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Breast cancer ( 23535729)
Interacting Genes		6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2	10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1
Entrez ID		146956	80198
HPRD ID		10937	09419
Ensembl ID		ENSG00000154920	ENSG00000172732
Uniprot IDs		Q96AY2	Q53ES5 Q96NY9
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S	2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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