EME1 and SLX4

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EME1	SLX4
Description		essential meiotic structure-specific endonuclease 1	SLX4 structure-specific endonuclease subunit
Image
GO Annotations	Cellular Component	Heterochromatin Nucleoplasm Nucleolus Holliday Junction Resolvase Complex	Chromosome, Telomeric Region Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding	DNA Binding Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Enzyme Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis	Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Type 2 diabetes ( 32499647)
Interacting Genes		6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2	8 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A UBC UBE2I
Entrez ID		146956	84464
HPRD ID		10937	12537
Ensembl ID		ENSG00000154920	ENSG00000188827
Uniprot IDs		Q96AY2	Q8IY92
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S	4M7C 4UYI 4ZOU
Enriched GO Terms of Interacting Partners?
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