PTGES2 and CEBPB

Data Source:
HPRD (in vivo, in vitro)

		PTGES2	CEBPB
Description		prostaglandin E synthase 2	CCAAT enhancer binding protein beta
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Mitochondrion Cytosol Integral Component Of Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm	Condensed Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix CHOP-C/EBP Complex
	Molecular Function	DNA Binding Protein Binding Protein Disulfide Oxidoreductase Activity Lyase Activity Heme Binding Glutathione Binding Prostaglandin-E Synthase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Histone Acetyltransferase Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Glutathione Metabolic Process Cyclooxygenase Pathway Neutrophil Degranulation Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Acute-phase Response Inflammatory Response Immune Response Memory Neuron Differentiation Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-4 Production Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Interleukin-1 Cellular Response To Organic Cyclic Compound Hepatocyte Proliferation Liver Regeneration Positive Regulation Of Cold-induced Thermogenesis Regulation Of Odontoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Sodium-dependent Phosphate Transport Regulation Of Dendritic Cell Differentiation
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Neutrophil degranulation	Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) ATF4 activates genes in response to endoplasmic reticulum stress Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional Regulation by VENTX Transcriptional regulation of granulopoiesis Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs			Quercetin
Diseases		Penile cancer
GWAS		Body mass index ( 26426971)	Bronchodilator response in asthma ( 25562107) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Meconium ileus in cystic fibrosis ( 30807572) Type 2 diabetes ( 30297969 32499647 30718926)
Interacting Genes		5 interacting genes: ADRB2 C1orf189 CEBPB EXOSC10 PTGFR	57 interacting genes: AR ATF2 ATF4 CAMK2A CCL3 CCNT1 CDK9 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIB1 TRIM28
Entrez ID		80142	1051
HPRD ID		07458	01801
Ensembl ID		ENSG00000148334	ENSG00000172216
Uniprot IDs		A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7	P17676
PDB IDs			1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43 6MG1 6MG2 6MG3
Enriched GO Terms of Interacting Partners?
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