PIP4K2C and PJA1

Data Source:
BioGRID (enzymatic study)

		PIP4K2C	PJA1
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	praja ring finger ubiquitin ligase 1
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GO Annotations	Cellular Component	Nucleoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Organelle Extracellular Exosome	Cytoplasm
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Identical Protein Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	Protein Ubiquitination Protein Catabolic Process
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Rheumatoid arthritis ( 18794853)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		4 interacting genes: APP BTK FBXO25 PJA1	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		79837	64219
HPRD ID		15138	02335
Ensembl ID		ENSG00000166908	ENSG00000181191
Uniprot IDs		B3KQV3 Q8TBX8	Q8NG27
PDB IDs		2GK9	2L0B
Enriched GO Terms of Interacting Partners?
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