GAD2 and SYCE2

Data Source:
BioGRID (two hybrid)

		GAD2	SYCE2
Description		glutamate decarboxylase 2	synaptonemal complex central element protein 2
Image
GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Central Element Nucleoplasm Chromosome
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug	Synaptonemal Complex Assembly Cell Division
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling	Meiotic synapsis
Drugs		Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Lean body mass ( 28552196)	Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494)
Interacting Genes		45 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BSND CACNG1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A GAD1 HIGD1C LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TMEM159 TNFRSF10D TSPAN33	13 interacting genes: CCDC196 CDC37 GAD2 HOMER1 IFT20 KIFC3 MED11 MED4 NAP1L5 TEX12 TRIM69 TRIML2 TSNAX
Entrez ID		2572	256126
HPRD ID		11817	19522
Ensembl ID		ENSG00000136750	ENSG00000161860
Uniprot IDs		Q05329 Q5VZ30	Q6PIF2
PDB IDs		1ES0 2OKK	6R17
Enriched GO Terms of Interacting Partners?
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