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VKORC1 and CD81
Data Source:
BioGRID
(two hybrid)
VKORC1
CD81
Description
vitamin K epoxide reductase complex subunit 1
CD81 molecule
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Immunological Synapse
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Basal Plasma Membrane
Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Vesicle
Extracellular Exosome
Tetraspanin-enriched Microdomain
Molecular Function
Protein Binding
Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity
Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity
Quinone Binding
Virus Receptor Activity
Integrin Binding
Protein Binding
Cholesterol Binding
MHC Class II Protein Complex Binding
MHC Class II Protein Binding
Transferrin Receptor Binding
Biological Process
Blood Coagulation
Response To Organonitrogen Compound
Response To Organic Cyclic Compound
Drug Metabolic Process
Peptidyl-glutamic Acid Carboxylation
Regulation Of Blood Coagulation
Vitamin K Metabolic Process
Response To Antibiotic
Bone Development
Activation Of MAPK Activity
Immunological Synapse Formation
Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Protein Localization
Positive Regulation Of Cell Population Proliferation
Myoblast Fusion Involved In Skeletal Muscle Regeneration
Regulation Of Complement Activation
Positive Regulation Of B Cell Proliferation
Receptor Internalization
Regulation Of Protein Stability
Macrophage Fusion
CD4-positive, Alpha-beta T Cell Costimulation
Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Viral Entry Into Host Cell
Receptor-mediated Virion Attachment To Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Positive Regulation Of B Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Protein Localization To Lysosome
Positive Regulation Of Protein Exit From Endoplasmic Reticulum
Cellular Response To Low-density Lipoprotein Particle Stimulus
Protein Localization To Plasma Membrane
Osteoclast Fusion
Positive Regulation Of Receptor Clustering
Positive Regulation Of Protein Catabolic Process In The Vacuole
Regulation Of Macrophage Migration
Positive Regulation Of Adaptive Immune Memory Response
Positive Regulation Of T-helper 2 Cell Cytokine Production
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways
Metabolism of vitamin K
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Regulation of Complement cascade
Drugs
Menadione
Dicoumarol
Phenindione
Warfarin
Phenprocoumon
Acenocoumarol
Diseases
Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Body fat distribution (arm fat ratio) (
30664634
)
Warfarin maintenance dose (
18535201
20833655
19300499
26265036
)
Warfarin maintenance dose (adjusted for clinical factors) (
28686080
)
Malaria (
31844061
)
Interacting Genes
93 interacting genes:
AHSG
APLP2
APOA1
APOA2
APOC1
APOC3
APOC4
ARL6IP5
ASGR1
ASGR2
ATP5MC3
ATP6AP2
BCAP31
C1S
CCDC12
CCDC167
CD63
CD81
CD9
CLDN10
CNN3
COMT
CPLX4
CREB3
CREB3L1
CXADR
DPM2
ECHDC1
FAM209A
FAM210B
FGG
FGL1
FIS1
FTL
GJB1
GORAB
GPR152
HAMP
HDAC6
HOMER2
HP
HPR
HSD17B7
IFITM3
JAGN1
KCNK17
LIG4
LMNA
MANBAL
METTL7B
MSMO1
MSRB1
MT1X
MUC1
PCDH1
PCMT1
PDIA6
PIGH
PLP2
PPA2
PPIB
PROCR
REEP5
RMDN1
RMDN3
RMND5A
SAA1
SAT1
SERPINA1
SLC15A3
SLC22A2
SLC25A1
SLC31A2
SLC7A14
SNORA12
SPTSSA
STAT6
SURF4
TF
TMBIM4
TMEM120A
TMEM134
TMEM176A
TMEM230
TMEM242
TMEM256
TMEM35B
TMEM45B
TRAM1
TREX1
VAPB
YIF1A
ZCCHC24
58 interacting genes:
ADRA1A
ADRB2
AQP6
BDKRB2
BST2
CCR2
CCR9
CD19
CD9
CHRM4
CPLX4
CSNK2B
DLG5
EBP
ERGIC3
F2RL1
FAM209A
GJA4
GLP1R
GORAB
GPR152
GPR35
GPX8
HNRNPD
HRH1
HTR4
IFITM1
IGSF8
INO80B
ITGA4
JAK3
KIT
LBR
LHFPL5
LMNA
MC4R
MCEE
MRPS18B
MYOC
NEMP1
OXTR
PDZK1IP1
PTGFRN
RBBP6
RNF128
SAR1A
SDHAF4
SHC1
SIRPA
SLC26A6
STX1A
THAP4
TMX2
TREX1
TSHR
TSPAN4
VKORC1
ZBTB16
Entrez ID
79001
975
HPRD ID
10540
08924
Ensembl ID
ENSG00000167397
ENSG00000110651
Uniprot IDs
A0A0S2Z5X7
A0A0S2Z6I4
Q9BQB6
A0A024RCB7
E9PJK1
P60033
PDB IDs
1G8Q
1IV5
2AVZ
3X0E
5DFV
5DFW
5M2C
5M33
5M3D
5M3T
5M4R
5TCX
6EJG
6EJM
6EK2
6U9S
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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