CD81 and HRH1

Data Source:
BioGRID (two hybrid)

		CD81	HRH1
Description		CD81 molecule	histamine receptor H1
Image
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Activation Of MAPK Activity Immunological Synapse Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Protein Localization Positive Regulation Of Cell Population Proliferation Myoblast Fusion Involved In Skeletal Muscle Regeneration Regulation Of Complement Activation Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Memory Visual Learning Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Regulation Of Vascular Permeability Positive Regulation Of Vasoconstriction Inositol Phosphate-mediated Signaling Regulation Of Synaptic Plasticity Eosinophil Chemotaxis Cellular Response To Histamine G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade	Histamine receptors G alpha (q) signalling events
Drugs			Citalopram Benzatropine Ziprasidone Clemastine Amitriptyline Olanzapine Cetirizine Terfenadine Buclizine Clozapine Doxylamine Mirtazapine Dexbrompheniramine Loxapine Promazine Triprolidine Prochlorperazine Cyproheptadine Loratadine Imipramine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Hydroxyzine Cinnarizine Astemizole Trazodone Paroxetine Azatadine Trimipramine Risperidone Meclizine Carbinoxamine Epinastine Benzquinamide Olopatadine Propiomazine Tripelennamine Tolazoline Brompheniramine Methdilazine Ketotifen Maprotiline Fexofenadine Desloratadine Azelastine Dimenhydrinate Promethazine Mequitazine Diphenhydramine Emedastine Levocabastine Chlorpheniramine Doxepin Diphenylpyraline Desipramine Orphenadrine Escitalopram Cyclizine Quetiapine Bromodiphenhydramine Aripiprazole Chlorprothixene Alimemazine Paliperidone Methotrimeprazine Aceprometazine Phenindamine Pheniramine Zuclopenthixol Clofedanol Flunarizine Bepotastine Tesmilifene Iloperidone HY10275 OBE101 SO-101 Histamine Epicept NP-1 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Levocetirizine Esmirtazapine Mepyramine Betahistine Alcaftadine Antazoline Chloropyramine Dimetindene Isothipendyl Perospirone Chlorcyclizine Butriptyline Dosulepin Lorpiprazole Acrivastine Dexchlorpheniramine maleate Thonzylamine Bilastine Rupatadine Aripiprazole lauroxil
Diseases
GWAS		Malaria ( 31844061)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Mortality in sepsis ( 27639821) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 27618447 27618452)
Interacting Genes		58 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16	11 interacting genes: ADGRA3 ATP6V0A1 CD81 CNBP DHRS7 LIMS2 MAT2B SLC35B1 SLC43A2 WLS YIPF3
Entrez ID		975	3269
HPRD ID		08924	02544
Ensembl ID		ENSG00000110651	ENSG00000196639
Uniprot IDs		A0A024RCB7 E9PJK1 P60033	P35367
PDB IDs		1G8Q 1IV5 2AVZ 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S	3RZE
Enriched GO Terms of Interacting Partners?
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