VKORC1 and TMEM45B

Data Source:
BioGRID (two hybrid)

		VKORC1	TMEM45B
Description		vitamin K epoxide reductase complex subunit 1	transmembrane protein 45B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Integral Component Of Membrane
	Molecular Function	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding	Protein Binding
	Biological Process	Blood Coagulation Response To Organonitrogen Compound Response To Organic Cyclic Compound Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Vitamin K Metabolic Process Response To Antibiotic Bone Development
Pathways		Metabolism of vitamin K
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases		Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Breast cancer ( 22383897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Type 2 diabetes ( 22238593)
Interacting Genes		93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL METTL7B MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24	41 interacting genes: ANKRD46 APOD APOL2 AQP1 BMP10 C3orf52 C4orf3 CACNG1 CDS2 CYB561D2 DOLK FAM3C FKBP8 GIMAP1 INSIG2 LAT NSG1 PLN PLP1 PLPP4 SEC22A SEC23A SMAGP SMIM1 SNORC SYNGR1 TINAG TMEM128 TMEM218 TMEM229B TMEM243 TMEM254 TMEM60 TMEM97 TNFRSF10C TREX1 TSPAN33 UBE2G2 UPK1B VAMP5 VKORC1
Entrez ID		79001	120224
HPRD ID		10540	14020
Ensembl ID		ENSG00000167397	ENSG00000151715
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	Q96B21
PDB IDs
Enriched GO Terms of Interacting Partners?
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