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VKORC1 and CREB3
Data Source:
BioGRID
(two hybrid)
VKORC1
CREB3
Description
vitamin K epoxide reductase complex subunit 1
cAMP responsive element binding protein 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Integral Component Of Membrane
Molecular Function
Protein Binding
Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity
Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity
Quinone Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
CAMP Response Element Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Blood Coagulation
Response To Organonitrogen Compound
Response To Organic Cyclic Compound
Drug Metabolic Process
Peptidyl-glutamic Acid Carboxylation
Regulation Of Blood Coagulation
Vitamin K Metabolic Process
Response To Antibiotic
Bone Development
Regulation Of Transcription By RNA Polymerase II
Chemotaxis
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Viral Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Monocyte Chemotaxis
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways
Metabolism of vitamin K
CREB3 factors activate genes
CREB3 factors activate genes
Drugs
Menadione
Dicoumarol
Phenindione
Warfarin
Phenprocoumon
Acenocoumarol
Diseases
Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Body fat distribution (arm fat ratio) (
30664634
)
Warfarin maintenance dose (
18535201
20833655
19300499
26265036
)
Warfarin maintenance dose (adjusted for clinical factors) (
28686080
)
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
93 interacting genes:
AHSG
APLP2
APOA1
APOA2
APOC1
APOC3
APOC4
ARL6IP5
ASGR1
ASGR2
ATP5MC3
ATP6AP2
BCAP31
C1S
CCDC12
CCDC167
CD63
CD81
CD9
CLDN10
CNN3
COMT
CPLX4
CREB3
CREB3L1
CXADR
DPM2
ECHDC1
FAM209A
FAM210B
FGG
FGL1
FIS1
FTL
GJB1
GORAB
GPR152
HAMP
HDAC6
HOMER2
HP
HPR
HSD17B7
IFITM3
JAGN1
KCNK17
LIG4
LMNA
MANBAL
METTL7B
MSMO1
MSRB1
MT1X
MUC1
PCDH1
PCMT1
PDIA6
PIGH
PLP2
PPA2
PPIB
PROCR
REEP5
RMDN1
RMDN3
RMND5A
SAA1
SAT1
SERPINA1
SLC15A3
SLC22A2
SLC25A1
SLC31A2
SLC7A14
SNORA12
SPTSSA
STAT6
SURF4
TF
TMBIM4
TMEM120A
TMEM134
TMEM176A
TMEM230
TMEM242
TMEM256
TMEM35B
TMEM45B
TRAM1
TREX1
VAPB
YIF1A
ZCCHC24
205 interacting genes:
ABHD16A
ACKR2
ACSF2
ACSL5
ADTRP
AGER
AGPAT3
ALG3
ALG8
APH1A
APOA2
APOD
APPBP2
AQP1
AQP2
AQP4
AQP5
ATF3
ATF4
ATP6AP2
ATP6V0C
BCAP29
BCAT2
BCL2L1
BIK
BNIP2
BNIP3
BTN2A2
C2
C3orf52
CACFD1
CCR1
CD207
CD82
CDS2
CEBPG
CELA3A
CES1
CFHR5
CGRRF1
CHMP7
CLCN7
CLDN19
CLDND2
CLP1
CMTM5
CNPY3
CREB3L1
CREB3L3
CT45A5
CTSW
CYB561
CYB5B
CYBC1
CYBRD1
CYP4F2
DDIT3
DNAJC30
DOLK
DRAM1
EBP
EMC6
EMD
ERG28
FA2H
FAM3A
FAM3C
FDFT1
FDPS
FIS1
FMO1
FMO3
FXYD3
FXYD6
GJA1
GJB2
GYPA
HCFC1
HDAC3
HMOX1
HVCN1
ICAM4
IGFBP5
ITM2B
JUN
KCNK1
KLHL30-AS1
KRTCAP2
LAT
LHFPL5
LILRB5
LMBR1L
LMNA
LPCAT2
LTA
MAL2
MALL
MARCHF5
MFSD11
MFSD5
MGST2
MRPL57
MS4A1
MYADM
NAA10
NDUFB6
NEU1
NFE2L2
NFE2L3
NFIL3
NKG7
NRG4
ORMDL1
OS9
P4HA2
PLLP
PLN
PLP1
PLPP1
PLTP
PMP22
PNLIPRP1
PSENEN
PTCH1
PTDSS1
PTPN9
RAB23
RABAC1
RHEB
RIMS3
RPRM
RPS3A
RRAS2
RUSF1
SACM1L
SAR1B
SCAMP4
SCAMP5
SCLY
SCP2
SEC22B
SEC61G
SELENOK
SERINC1
SFT2D2
SFTPC
SFXN3
SHMT2
SLC19A3
SLC29A1
SLC29A2
SLC29A3
SLC2A3
SLC2A4
SLC30A2
SLC35C2
SLC38A1
SLC39A13
SLC41A2
SLC41A3
SLC49A3
SLC50A1
SLC7A9
SPOCK3
SQLE
ST6GAL2
STARD3
STX7
STX8
SYNGR1
SYNPR
TAP1
TECR
TIMM17B
TIMM23B
TM4SF4
TMEM100
TMEM115
TMEM140
TMEM14A
TMEM14B
TMEM14C
TMEM19
TMEM203
TMEM222
TMEM230
TMEM234
TMEM243
TMEM51
TMEM54
TRAM1
TRAM1L1
TSPAN2
TSPAN4
TSPAN7
TTLL5
UBE2J1
UNC50
USE1
VKORC1
VTI1B
YIPF2
ZDHHC11
ZDHHC21
ZDHHC9
Entrez ID
79001
10488
HPRD ID
10540
07339
Ensembl ID
ENSG00000167397
ENSG00000107175
Uniprot IDs
A0A0S2Z5X7
A0A0S2Z6I4
Q9BQB6
O43889
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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