CD81 and SLC26A6

Data Source:
BioGRID (two hybrid)

		CD81	SLC26A6
Description		CD81 molecule	solute carrier family 26 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Vesicle Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Brush Border Membrane Vesicle Chloride Channel Complex Sperm Midpiece
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding	Chloride Channel Activity Secondary Active Sulfate Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Anion:anion Antiporter Activity Formate Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Formate Efflux Transmembrane Transporter Activity Oxalate Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Activation Of MAPK Activity Immunological Synapse Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Protein Localization Positive Regulation Of Cell Population Proliferation Myoblast Fusion Involved In Skeletal Muscle Regeneration Regulation Of Complement Activation Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Ion Transport Chloride Transport Sulfate Transport Bicarbonate Transport Formate Transport Mannitol Transport Oxalate Transport Transepithelial Chloride Transport Epithelial Fluid Transport Oxalic Acid Secretion Sperm Capacitation Intestinal Absorption Regulation Of Intracellular PH Intracellular PH Elevation Transepithelial Transport Cellular Response To CAMP Cellular Response To Fructose Stimulus Cellular Response To Interferon-gamma Sulfate Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Dipeptide Transmembrane Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade	Multifunctional anion exchangers
Drugs
Diseases
GWAS		Malaria ( 31844061)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		58 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16	12 interacting genes: APOL2 AQP2 BET1 CD81 ERG28 LAT PDZK1 PLP1 SNORC TF TMEM128 TMEM201
Entrez ID		975	65010
HPRD ID		08924	10235
Ensembl ID		ENSG00000110651	ENSG00000225697
Uniprot IDs		A0A024RCB7 E9PJK1 P60033	A0A0C4DFT5 G3XAC1 Q96MZ1 Q9BXS9 Q9Y3Y1
PDB IDs		1G8Q 1IV5 2AVZ 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S
Enriched GO Terms of Interacting Partners?
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