CRELD1 and POLA2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CRELD1	POLA2
Description		cysteine rich with EGF like domains 1	DNA polymerase alpha 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Collagen-containing Extracellular Matrix	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	Endocardial Cushion Development Cardiac Septum Development Protein Phosphopantetheinylation	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases		Atrioventricular septal defect; Atrioventricular canal defect
GWAS		Blood protein levels ( 30072576 29875488)	Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		14 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HTR2C KAT5 MAP3K1 MTNR1B POLA2 PTN SETDB1 ZNF408	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		78987	23649
HPRD ID		06206	10160
Ensembl ID		ENSG00000163703	ENSG00000014138
Uniprot IDs		A0A024R2G1 Q96HD1	Q14181
PDB IDs			2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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