CRELD1 and HTR2C

Data Source:
BioGRID (two hybrid)

		CRELD1	HTR2C
Description		cysteine rich with EGF like domains 1	5-hydroxytryptamine receptor 2C
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Collagen-containing Extracellular Matrix	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	Endocardial Cushion Development Cardiac Septum Development Protein Phosphopantetheinylation	Behavioral Fear Response Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Serotonin receptors G alpha (q) signalling events
Drugs			Tramadol Ziprasidone Methysergide Cabergoline Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Epicept NP-1 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Captodiame Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases		Atrioventricular septal defect; Atrioventricular canal defect
GWAS		Blood protein levels ( 30072576 29875488)
Interacting Genes		14 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HTR2C KAT5 MAP3K1 MTNR1B POLA2 PTN SETDB1 ZNF408	34 interacting genes: APBA1 ARRB2 ATP2B3 ATP6AP2 ATP6V0C C4orf3 CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MFSD14A MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1
Entrez ID		78987	3358
HPRD ID		06206	02429
Ensembl ID		ENSG00000163703	ENSG00000147246
Uniprot IDs		A0A024R2G1 Q96HD1	K9J958 P28335
PDB IDs			6BQG 6BQH
Enriched GO Terms of Interacting Partners?
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