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TRIM25 and UBE2V1
Data Source:
BioGRID
(pull down)
TRIM25
UBE2V1
Description
tripartite motif containing 25
ubiquitin conjugating enzyme E2 V1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Cytoplasmic Stress Granule
Nuclear Body
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ubiquitin Conjugating Enzyme Complex
Protein-containing Complex
UBC13-UEV1A Complex
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
RNA Binding
Protein Binding
Ligase Activity
RIG-I Binding
Cadherin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Viral Process
Translesion Synthesis
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Type I Interferon Production
Regulation Of Protein Localization
Response To Vitamin D
RIG-I Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Estrogen
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Leukemia Inhibitory Factor
Activation Of MAPK Activity
Protein Polyubiquitination
Regulation Of DNA Repair
Postreplication Repair
Regulation Of Transcription, DNA-templated
JNK Cascade
Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Ovarian tumor domain proteases
Interferon gamma signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
18391951
)
Lean body mass (
28552196
)
Interacting Genes
57 interacting genes:
AMFR
APC
DDX58
ERCC2
ERG
ESR1
GATA1
GRIK2
MAP3K13
MEIS2
MIR1-1
MIR155
MIR16-2
MIR19B2
MIR205
MIR206
MIR21
MIR221
MIR25
MIR29A
MIR29B1
MIR34A
MIR363
MIR7-1
MIR92A1
MIR92A2
MIR98
MIRLET7A1
MIRLET7A3
MTA1
OTUB2
PAX2
PITX2
PLAAT4
RBCK1
RNF31
SFN
STK11
STK38
SUMO2
TFG
TRAF6
TRIM8
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2J2
UBE2L3
UBE2L6
UBE2N
UBE2V1
USP15
USP39
YWHAQ
ZNF24
47 interacting genes:
ARIH2
BIRC2
BIRC3
BIRC8
CTAG1A
CTAG1B
DAZAP2
DTX3
DZIP3
FAM168A
KITLG
MAP3K1
MID1
MKRN3
PELI1
PELI3
PRKN
PSMD14
RC3H1
RC3H2
RNF10
RNF111
RNF14
RNF144A
RNF185
RNF2
RNF5
SHISA4
SMURF1
STUB1
SUMO4
TRAF2
TRAF3IP2
TRAF6
TRIM25
TRIM32
TRIM39
TRIM5
TRIM8
UBC
UBE2N
UBOX5
UBQLN1
UBQLN2
XBP1
XIAP
ZNRF1
Entrez ID
7706
7335
HPRD ID
02711
04294
Ensembl ID
ENSG00000121060
ENSG00000244687
Uniprot IDs
Q14258
G3V2F7
Q13404
PDB IDs
4CFG
4LTB
5EYA
5FER
5NT1
5NT2
6FLM
6FLN
2A4D
2C2V
2HLW
6D6I
Enriched GO Terms of Interacting Partners
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