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TRIM25 and ERCC2
Data Source:
BioGRID
(pull down)
TRIM25
ERCC2
Description
tripartite motif containing 25
ERCC excision repair 2, TFIIH core complex helicase subunit
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Cytoplasmic Stress Granule
Nuclear Body
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Cytoplasm
Spindle
Cytosol
CAK-ERCC2 Complex
MMXD Complex
Molecular Function
Transcription Coactivator Activity
RNA Binding
Protein Binding
Ligase Activity
RIG-I Binding
Cadherin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
DNA Helicase Activity
Damaged DNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Protein-macromolecule Adaptor Activity
5'-3' DNA Helicase Activity
Metal Ion Binding
Protein N-terminus Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Viral Process
Translesion Synthesis
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Type I Interferon Production
Regulation Of Protein Localization
Response To Vitamin D
RIG-I Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Estrogen
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Leukemia Inhibitory Factor
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nucleotide-excision Repair, DNA Duplex Unwinding
Response To Hypoxia
In Utero Embryonic Development
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Apoptotic Process
Response To Oxidative Stress
Chromosome Segregation
Aging
Cell Population Proliferation
Response To UV
UV Protection
Post-embryonic Development
Viral Process
Spinal Cord Development
Extracellular Matrix Organization
Bone Mineralization
Central Nervous System Myelin Formation
Nucleotide-excision Repair, DNA Incision
Multicellular Organism Growth
Hair Cell Differentiation
Embryonic Cleavage
Erythrocyte Maturation
Positive Regulation Of DNA Binding
Positive Regulation Of Mitotic Recombination
Embryonic Organ Development
Hair Follicle Maturation
Hematopoietic Stem Cell Differentiation
Global Genome Nucleotide-excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Ovarian tumor domain proteases
Interferon gamma signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
Cytosolic iron-sulfur cluster assembly
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Height (
18391951
)
Lean body mass (
28552196
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Lung Cancer (DNA repair capacity) (
23108145
)
Interacting Genes
57 interacting genes:
AMFR
APC
DDX58
ERCC2
ERG
ESR1
GATA1
GRIK2
MAP3K13
MEIS2
MIR1-1
MIR155
MIR16-2
MIR19B2
MIR205
MIR206
MIR21
MIR221
MIR25
MIR29A
MIR29B1
MIR34A
MIR363
MIR7-1
MIR92A1
MIR92A2
MIR98
MIRLET7A1
MIRLET7A3
MTA1
OTUB2
PAX2
PITX2
PLAAT4
RBCK1
RNF31
SFN
STK11
STK38
SUMO2
TFG
TRAF6
TRIM8
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2J2
UBE2L3
UBE2L6
UBE2N
UBE2V1
USP15
USP39
YWHAQ
ZNF24
17 interacting genes:
AR
CDK1
CDK7
ERCC3
ERCC5
GTF2E1
GTF2H1
GTF2H2
GTF2H2C_2
GTF2H3
HERC5
MNAT1
MTDH
RAD51
RAD52
TP53
TRIM25
Entrez ID
7706
2068
HPRD ID
02711
00530
Ensembl ID
ENSG00000121060
ENSG00000104884
Uniprot IDs
Q14258
P18074
PDB IDs
4CFG
4LTB
5EYA
5FER
5NT1
5NT2
6FLM
6FLN
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
Enriched GO Terms of Interacting Partners
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