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TRIM25 and DDX58
Data Source:
BioGRID
(imaging technique, enzymatic study, imaging technique)
TRIM25
DDX58
Description
tripartite motif containing 25
DExD/H-box helicase 58
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Cytoplasmic Stress Granule
Nuclear Body
Cytoplasm
Cytosol
Plasma Membrane
Bicellular Tight Junction
Actin Cytoskeleton
Ruffle Membrane
Ribonucleoprotein Complex
Molecular Function
Transcription Coactivator Activity
RNA Binding
Protein Binding
Ligase Activity
RIG-I Binding
Cadherin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
RNA Helicase Activity
Double-stranded RNA Binding
Single-stranded RNA Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Viral Process
Translesion Synthesis
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Type I Interferon Production
Regulation Of Protein Localization
Response To Vitamin D
RIG-I Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Estrogen
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Defense Response To Virus By Host
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Detection Of Virus
Response To Virus
Positive Regulation Of Gene Expression
Viral Process
Protein Deubiquitination
Regulation Of Cell Migration
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Type III Interferon Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus
RIG-I Signaling Pathway
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Defense Response To Virus
Positive Regulation Of Response To Cytokine Stimulus
Cellular Response To Exogenous DsRNA
Antiviral Innate Immune Response
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Ovarian tumor domain proteases
Interferon gamma signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ub-specific processing proteases
Ovarian tumor domain proteases
OAS antiviral response
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Height (
18391951
)
Lean body mass (
28552196
)
Blood protein levels (
30072576
)
Bone mineral density (spine) and age at menarche (
26312577
)
Hematocrit (
27863252
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory skin disease (
25574825
)
Metabolite levels (
23823483
)
Psoriasis (
25903422
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Red blood cell count (
27863252
)
Interacting Genes
57 interacting genes:
AMFR
APC
DDX58
ERCC2
ERG
ESR1
GATA1
GRIK2
MAP3K13
MEIS2
MIR1-1
MIR155
MIR16-2
MIR19B2
MIR205
MIR206
MIR21
MIR221
MIR25
MIR29A
MIR29B1
MIR34A
MIR363
MIR7-1
MIR92A1
MIR92A2
MIR98
MIRLET7A1
MIRLET7A3
MTA1
OTUB2
PAX2
PITX2
PLAAT4
RBCK1
RNF31
SFN
STK11
STK38
SUMO2
TFG
TRAF6
TRIM8
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2J2
UBE2L3
UBE2L6
UBE2N
UBE2V1
USP15
USP39
YWHAQ
ZNF24
16 interacting genes:
CYLD
MAVS
PRKCG
RNF122
RNF135
SNX5
THAP12
TRIM25
TRIM40
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2K
USP15
USP3
Entrez ID
7706
23586
HPRD ID
02711
13131
Ensembl ID
ENSG00000121060
ENSG00000107201
Uniprot IDs
Q14258
O95786
PDB IDs
4CFG
4LTB
5EYA
5FER
5NT1
5NT2
6FLM
6FLN
2LWD
2LWE
2QFB
2QFD
2RMJ
2YKG
3LRN
3LRR
3NCU
3OG8
3ZD6
3ZD7
4AY2
4BPB
4NQK
4ON9
4P4H
5E3H
5F98
5F9F
5F9H
6GPG
6KYV
Enriched GO Terms of Interacting Partners
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