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TRIM25 and PLAAT4
Data Source:
BioGRID
(pull down)
TRIM25
PLAAT4
Description
tripartite motif containing 25
phospholipase A and acyltransferase 4
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Cytoplasmic Stress Granule
Nuclear Body
Cytoplasm
Cytosol
Membrane
Integral Component Of Membrane
Molecular Function
Transcription Coactivator Activity
RNA Binding
Protein Binding
Ligase Activity
RIG-I Binding
Cadherin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Phospholipase A2 Activity
Protein Binding
Phospholipase A1 Activity
N-acyltransferase Activity
Phosphatidylserine 1-acylhydrolase Activity
1-acyl-2-lysophosphatidylserine Acylhydrolase Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Viral Process
Translesion Synthesis
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Type I Interferon Production
Regulation Of Protein Localization
Response To Vitamin D
RIG-I Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Estrogen
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Leukemia Inhibitory Factor
Phospholipid Metabolic Process
Negative Regulation Of Cell Population Proliferation
Lipid Catabolic Process
Phosphatidylethanolamine Acyl-chain Remodeling
Positive Regulation Of Keratinocyte Differentiation
N-acylphosphatidylethanolamine Metabolic Process
Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Ovarian tumor domain proteases
Interferon gamma signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
Acyl chain remodelling of PE
Drugs
Diseases
GWAS
Height (
18391951
)
Lean body mass (
28552196
)
Interacting Genes
57 interacting genes:
AMFR
APC
DDX58
ERCC2
ERG
ESR1
GATA1
GRIK2
MAP3K13
MEIS2
MIR1-1
MIR155
MIR16-2
MIR19B2
MIR205
MIR206
MIR21
MIR221
MIR25
MIR29A
MIR29B1
MIR34A
MIR363
MIR7-1
MIR92A1
MIR92A2
MIR98
MIRLET7A1
MIRLET7A3
MTA1
OTUB2
PAX2
PITX2
PLAAT4
RBCK1
RNF31
SFN
STK11
STK38
SUMO2
TFG
TRAF6
TRIM8
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2J2
UBE2L3
UBE2L6
UBE2N
UBE2V1
USP15
USP39
YWHAQ
ZNF24
6 interacting genes:
HRAS
PIK3R3
SGTA
TGM1
TRIM25
UBE2I
Entrez ID
7706
5920
HPRD ID
02711
05479
Ensembl ID
ENSG00000121060
ENSG00000133321
Uniprot IDs
Q14258
Q9UL19
PDB IDs
4CFG
4LTB
5EYA
5FER
5NT1
5NT2
6FLM
6FLN
2LKT
2MY9
Enriched GO Terms of Interacting Partners
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