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TRIM25 and OTUB2
Data Source:
BioGRID
(two hybrid)
TRIM25
OTUB2
Description
tripartite motif containing 25
OTU deubiquitinase, ubiquitin aldehyde binding 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Cytoplasmic Stress Granule
Nuclear Body
Nucleus
Molecular Function
Transcription Coactivator Activity
RNA Binding
Protein Binding
Ligase Activity
RIG-I Binding
Cadherin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
NEDD8-specific Protease Activity
Ubiquitin Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Viral Process
Translesion Synthesis
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Type I Interferon Production
Regulation Of Protein Localization
Response To Vitamin D
RIG-I Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Estrogen
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Leukemia Inhibitory Factor
Protein Deubiquitination
Protein Phosphopantetheinylation
Protein K11-linked Deubiquitination
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Negative Regulation Of Histone H2A K63-linked Ubiquitination
Negative Regulation Of Double-strand Break Repair
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Ovarian tumor domain proteases
Interferon gamma signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
Ovarian tumor domain proteases
Drugs
Diseases
GWAS
Height (
18391951
)
Lean body mass (
28552196
)
Interacting Genes
57 interacting genes:
AMFR
APC
DDX58
ERCC2
ERG
ESR1
GATA1
GRIK2
MAP3K13
MEIS2
MIR1-1
MIR155
MIR16-2
MIR19B2
MIR205
MIR206
MIR21
MIR221
MIR25
MIR29A
MIR29B1
MIR34A
MIR363
MIR7-1
MIR92A1
MIR92A2
MIR98
MIRLET7A1
MIRLET7A3
MTA1
OTUB2
PAX2
PITX2
PLAAT4
RBCK1
RNF31
SFN
STK11
STK38
SUMO2
TFG
TRAF6
TRIM8
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2J2
UBE2L3
UBE2L6
UBE2N
UBE2V1
USP15
USP39
YWHAQ
ZNF24
42 interacting genes:
APP
ARRDC3
CDIP1
CPSF6
DAZAP2
FAM168A
GLI2
KRT31
KRT40
LZTS2
MAGEA11
MID1
MID2
MKRN1
PHLDA2
PJA1
PLEKHB2
PMEPA1
RBCK1
REL
RFFL
RNF126
SIAH1
SPART
TP53BP2
TRAF6
TRIM2
TRIM25
TRIM26
TRIM27
TRIM39
TRIM5
TRIM54
TRIM55
TRIM63
TRIM8
TRIP6
U2AF2
UBC
UBE2N
USP21
USP28
Entrez ID
7706
78990
HPRD ID
02711
07620
Ensembl ID
ENSG00000121060
ENSG00000089723
Uniprot IDs
Q14258
Q96DC9
PDB IDs
4CFG
4LTB
5EYA
5FER
5NT1
5NT2
6FLM
6FLN
1TFF
4FJV
5QIO
5QIP
5QIQ
5QIR
5QIS
5QIT
5QIU
5QIV
5QIW
5QIX
5QIY
5QIZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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