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CYSRT1 and INS
Data Source:
BioGRID
(two hybrid)
CYSRT1
INS
Description
cysteine rich tail 1
insulin
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Exosome
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Transport Vesicle
Endosome Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Secretory Granule Lumen
Molecular Function
Protein Binding
Identical Protein Binding
Protease Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Hormone Activity
Protein Binding
Identical Protein Binding
Biological Process
Positive Regulation Of Cytokine Production
Negative Regulation Of Acute Inflammatory Response
Glucose Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Cellular Amino Acid Metabolic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Acute-phase Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Nitric Oxide Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Transmembrane Transporter Activity
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Activation Of Protein Kinase B Activity
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Localization
Negative Regulation Of NAD(P)H Oxidase Activity
Wound Healing
Negative Regulation Of Protein Catabolic Process
Glucose Homeostasis
Positive Regulation Of MAPK Cascade
Cellular Protein Metabolic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Glycogen Catabolic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Proteolysis
Negative Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Insulin Receptor Signaling Pathway
Alpha-beta T Cell Activation
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Synaptic Plasticity
Regulation Of Protein Secretion
Negative Regulation Of Protein Secretion
Cognition
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Fatty Acid Homeostasis
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Respiratory Burst
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Dendritic Spine Maintenance
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Neuron Projection Maintenance
Negative Regulation Of Feeding Behavior
Pathways
Regulation of gene expression in beta cells
Insulin processing
Insulin processing
Synthesis, secretion, and deacylation of Ghrelin
Regulation of insulin secretion
COPI-mediated anterograde transport
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Amyloid fiber formation
Drugs
Zinc
M-Cresol
Myristic acid
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Maturity onset diabetes of the young (MODY)
Type I diabetes mellitus
Permanent neonatal diabetes mellitus (PNDM)
GWAS
Birth weight (
27680694
)
Celiac disease (
23936387
)
Latent autoimmune diabetes vs. type 2 diabetes (
30254083
)
Pediatric autoimmune diseases (
26301688
)
Prostate cancer (
19767753
)
Prostate cancer (SNP x SNP interaction) (
22219177
)
Type 1 diabetes (
30659077
21829393
17632545
25751624
32005708
19430480
17554260
31152121
)
Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) (
29310926
)
Type 1 diabetes in high risk HLA genotype individuals (time to event) (
29310926
)
Type 2 diabetes (
31324766
30297969
31049640
32499647
30718926
)
Interacting Genes
497 interacting genes:
A1CF
ACY3
ADAM12
ADAMTSL3
ADAMTSL4
ADAMTSL5
AGXT
ALDH3B1
ALPP
ANAPC11
ANKS1A
AQP1
AREG
ARHGAP33
ARHGAP9
ARID5A
ASTL
ATG9A
ATPAF2
ATXN7L2
AVPI1
B4GALT7
BAG3
BAG6
BAHD1
BAIAP2L1
BEX1
BEX2
BLCAP
BMP7
BRME1
BSCL2
C11orf16
C11orf87
C19orf54
C22orf39
C4orf45
C7orf31
C9orf24
CACNA1A
CACNA1S
CARD10
CARHSP1
CATSPER1
CBLL2
CBX2
CCDC120
CCDC187
CCDC28A-AS1
CCER1
CCNK
CD300LG
CDKL3
CELF5
CERCAM
CERK
CES1
CFAP206
CFP
CHCHD2
CHCHD3
CHIC2
CHRD
CHRNG
CLCNKA
CLDN19
CLDN2
CLEC18A
CNNM3
CNTF
COA5
COL8A1
COMP
CRCT1
CREB5
CRH
CRY2
CRYBA1
CRYBA2
CSF1
CST2
CST9L
CTRC
CTSG
CTSZ
CXCL16
CYP21A2
DACT2
DALRD3
DBF4B
DCDC2B
DDX43
DLGAP2
DMRT3
DNAJA3
DNASE1L3
DOCK2
DVL3
ECE1
ECM1
EFEMP1
EFEMP2
EMC7
ENKD1
EPS8L1
ERH
ESR2
ETNK2
FADS6
FAM102A
FAM124B
FAM214B
FAM221A
FAM221B
FAM71C
FAM83A
FAM90A1
FARS2
FASLG
FBXW5
FEZF1
FHL3
FOXD2
FOXD4L1
FOXD4L3
FOXH1
FRS3
FRZB
FZD10
GAS8
GATA2
GATA3
GATA5
GCSAM
GEM
GGN
GLB1L2
GLP1R
GNE
GNG13
GPANK1
GPATCH2L
GPRIN2
GPS2
GRN
GSTP1
GUCD1
HBZ
HCK
HDHD3
HEY2
HHEX
HLX
HOXA1
HOXB5
HOXB9
HOXC8
HOXC9
HR
HRG
HSBP1
HSD3B7
HSPA12B
HSPD1
HYAL2
HYPK
ICAM1
ICAM4
IL16
INCA1
INO80B
INPP5D
INS
IQCN
IQUB
ITGB2
ITGB4
ITGB5
JOSD1
KCNS2
KCTD15
KLHL38
KLK8
KPRP
KRT20
KRT31
KRT33B
KRT34
KRT81
KRT83
KRT85
KRT86
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP13-3
KRTAP13-4
KRTAP15-1
KRTAP19-1
KRTAP19-2
KRTAP19-3
KRTAP19-5
KRTAP19-6
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP3-1
KRTAP3-3
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
KRTAP9-2
KRTAP9-3
KRTAP9-8
KSR2
LAGE3
LASP1
LCE1A
LCE1B
LCE1C
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LENG8
LGALS9C
LMF2
LMNTD2
LMO3
LMO4
LNX1
LONRF1
LONRF3
LRFN4
LRRC29
LRRC41
LRRN4
LYVE1
MACROH2A1
MAPKBP1
MCRS1
MED25
MELTF
MEOX2
MFSD13A
MGAT5B
MIIP
MKRN3
MRPL23
MRPL40
MSRB1
MT1M
MTA1
MTNR1A
MXD3
MXI1
MYPOP
NBPF19
NDUFA9
NDUFAF3
NECTIN2
NECTIN3
NEU2
NEU4
NKD1
NMU
NOTCH2NLA
NOXA1
NPBWR2
NPDC1
NPPB
NR1D2
NR4A3
NSD1
NTAQ1
NTN4
NUBP2
NUFIP2
OLIG3
OR7A17
OTOS
OTX1
P2RX7
PATZ1
PCSK5
PDE9A
PGAP2
PGAP6
PHETA1
PHLDA1
PITX1
PITX2
PKD2
PKN1
PLA2G10
PLAC8
PLEKHN1
PLLP
POU4F2
PPP1CB
PPP1R32
PPY
PRF1
PRKAA2
PRKAB2
PROC
PROP1
PRPF31
PRR19
PRR22
PRR30
PRR34
PRR35
PTGDS
PTPMT1
PVR
QRICH1
R3HDM2
RAB3IL1
RALGDS
RAMAC
RAMP3
RASD1
RBM22
RBP3
RECK
REM2
RGL2
RGS3
RHBG
RHNO1
RNF38
RPS19BP1
RPUSD3
RSPO2
SAPCD2
SAXO1
SCARF1
SCNM1
SEMA3B
SEMA4C
SH3KBP1
SH3RF2
SHFL
SHISA6
SLC12A4
SLC13A5
SLC23A1
SLC25A18
SLC25A48
SLC43A2
SLC5A5
SLC6A20
SLIT1
SMARCC1
SMARCD1
SMARCE1
SMCP
SMOC1
SMUG1
SNRPB
SNRPC
SNX18
SOCS7
SPATA24
SPATA3
SPATA46
SPATA8
SPEF1
SPG7
SPON1
SPPL2C
SPRY1
SPTSSA
SRD5A2
SSC4D
STK16
TAPBPL
TBX2
TBX6
TCAF1
TCEA2
TCEANC
TCF7L2
TENT5B
TEPSIN
TEX37
TEX45
TFAP2D
TGFB1
THAP7
TIMM22
TLE5
TM7SF2
TMEM174
TNIP1
TNIP3
TNK2
TNS4
TRAPPC14
TREX1
TRIM42
TSGA10IP
TSPAN4
TTC23
TTPA
TYK2
UBXN7
USP54
UTP23
VASN
VENTX
VGLL3
VSTM4
VWC2
VWC2L
WDR25
WIF1
WNT11
WT1
YPEL3
YY1
ZBTB25
ZBTB4
ZCCHC14
ZDHHC1
ZFHX2
ZIC1
ZMYND10
ZNF124
ZNF266
ZNF319
ZNF330
ZNF34
ZNF408
ZNF414
ZNF417
ZNF419
ZNF438
ZNF439
ZNF440
ZNF441
ZNF446
ZNF497
ZNF552
ZNF575
ZNF580
ZNF581
ZNF587
ZNF648
ZNF669
ZNF683
ZNF696
ZNF764
ZNF775
ZNF786
ZNF835
ZNF837
ZNF843
ZNHIT1
ZSCAN5A
31 interacting genes:
ADAMTSL4
APP
CCN3
CPE
CRYAB
CTSB
CTSD
CTSE
CYSRT1
GCK
HLA-DQA2
HLA-DQB1
HSPA1A
HSPB1
IDE
IGF1R
IGFBP7
INSR
KMT2A
KRTAP1-1
KRTAP1-3
LRP2
MAPK6
NBPF19
NOTCH2NLA
PTEN
RB1
RGS20
SYTL4
TCF4
TXNDC17
Entrez ID
375791
3630
HPRD ID
14696
01455
Ensembl ID
ENSG00000197191
ENSG00000254647
Uniprot IDs
A8MQ03
B8A4K4
I3WAC9
P01308
PDB IDs
1A7F
1AI0
1AIY
1B9E
1BEN
1EFE
1EV3
1EV6
1EVR
1FU2
1FUB
1G7A
1G7B
1GUJ
1HIQ
1HIS
1HIT
1HLS
1HTV
1HUI
1IOG
1IOH
1J73
1JCA
1JCO
1JK8
1K3M
1KMF
1LKQ
1LPH
1MHI
1MHJ
1MSO
1OS3
1OS4
1Q4V
1QIY
1QIZ
1QJ0
1RWE
1SF1
1SJT
1SJU
1T0C
1T1K
1T1P
1T1Q
1TRZ
1TYL
1TYM
1UZ9
1VKT
1W8P
1XDA
1XGL
1XW7
1ZEG
1ZEH
1ZNJ
2AIY
2C8Q
2C8R
2CEU
2G54
2G56
2H67
2HH4
2HHO
2HIU
2JMN
2JUM
2JUU
2JUV
2JV1
2JZQ
2K91
2K9R
2KJJ
2KJU
2KQP
2KQQ
2KXK
2L1Y
2L1Z
2LGB
2LWZ
2M1D
2M1E
2M2M
2M2N
2M2O
2M2P
2MLI
2MPG
2MPI
2MVC
2MVD
2N2V
2N2W
2N2X
2OLY
2OLZ
2OM0
2OM1
2OMG
2OMH
2OMI
2OMQ
2QIU
2R34
2R35
2R36
2RN5
2VJZ
2VK0
2W44
2WBY
2WC0
2WRU
2WRV
2WRW
2WRX
2WS0
2WS1
2WS4
2WS6
2WS7
3AIY
3BXQ
3E7Y
3E7Z
3EXX
3FQ9
3HYD
3I3Z
3I40
3ILG
3INC
3IR0
3JSD
3KQ6
3P2X
3P33
3Q6E
3ROV
3TT8
3U4N
3UTQ
3UTS
3UTT
3V19
3V1G
3W11
3W12
3W13
3W7Y
3W7Z
3W80
3ZI3
3ZQR
3ZS2
3ZU1
4AIY
4AJX
4AJZ
4AK0
4AKJ
4CXL
4CXN
4CY7
4EFX
4EWW
4EWX
4EWZ
4EX0
4EX1
4EXX
4EY1
4EY9
4EYD
4EYN
4EYP
4F0N
4F0O
4F1A
4F1B
4F1C
4F1D
4F1F
4F1G
4F4T
4F4V
4F51
4F8F
4FG3
4FKA
4GBC
4GBI
4GBK
4GBL
4GBN
4IUZ
4IYD
4IYF
4NIB
4OGA
4P65
4RXW
4UNE
4UNG
4UNH
4WDI
4XC4
4Y19
4Y1A
4Z76
4Z77
4Z78
5AIY
5BOQ
5BPO
5BQQ
5BTS
5C0D
5CJO
5CNY
5CO2
5CO6
5CO9
5E7W
5EMS
5EN9
5ENA
5HPR
5HPU
5HQI
5HRQ
5HYJ
5MAM
5MHD
5MT3
5MT9
5MWQ
5T7R
5UDP
5UOZ
5UQA
5URT
5URU
5USP
5USS
5USV
5UU2
5UU3
5UU4
5VIZ
5WBT
5WDM
5WOB
6B3Q
6B70
6BFC
6CE7
6CE9
6CEB
6CK2
6GNQ
6GV0
6H3M
6HN5
6JK8
6JR3
6K59
6NWV
6O17
6P4Z
6S34
6S4I
6S4J
6SOF
6TYH
6U46
6VEP
6VET
6X4X
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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