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EZR and DLG1
Data Source:
BioGRID
(proximity labelling technology)
HPRD
(in vitro)
EZR
DLG1
Description
ezrin
discs large MAGUK scaffold protein 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Ruffle
Immunological Synapse
Uropod
Extracellular Space
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Brush Border
Focal Adhesion
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Extrinsic Component Of Membrane
Filopodium
T-tubule
Cortical Cytoskeleton
Microvillus Membrane
Vesicle
Ruffle Membrane
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Cell Body
Microspike
Plasma Membrane Raft
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cell Tip
Extracellular Exosome
Cell Periphery
Astrocyte Projection
Schwann Cell Microvillus
Cytoplasmic Side Of Apical Plasma Membrane
Immunological Synapse
Basement Membrane
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Microtubule
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Ionotropic Glutamate Receptor Complex
Cytoplasmic Side Of Plasma Membrane
Intercalated Disc
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Cell Junction
Cell Projection Membrane
Neuromuscular Junction
Node Of Ranvier
Myelin Sheath Abaxonal Region
Sarcolemma
Neuron Projection
Lateral Loop
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
MPP7-DLG1-LIN7 Complex
Synaptic Membrane
Postsynaptic Density Membrane
Glutamatergic Synapse
Molecular Function
RNA Binding
Actin Binding
Protein Binding
Microtubule Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Kinase A Catalytic Subunit Binding
Protein Kinase A Regulatory Subunit Binding
Identical Protein Binding
S100 Protein Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Protein Kinase A Binding
ATPase Binding
Disordered Domain Specific Binding
Guanylate Kinase Activity
Phosphoprotein Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Cytoskeletal Protein Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Binding
Ion Channel Binding
Cadherin Binding
Molecular Adaptor Activity
L27 Domain Binding
Structural Constituent Of Postsynaptic Density
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Intestinal D-glucose Absorption
Sphingosine-1-phosphate Receptor Signaling Pathway
Leukocyte Cell-cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Regulation Of Cell Size
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Gland Morphogenesis
Membrane To Membrane Docking
Microvillus Assembly
Astral Microtubule Organization
Actin Cytoskeleton Reorganization
Receptor Internalization
Regulation Of Microvillus Length
Negative Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Protein-containing Complex Localization
Positive Regulation Of Multicellular Organism Growth
Cortical Microtubule Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Filopodium Assembly
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Protein Secretion
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Establishment Of Centrosome Localization
Establishment Of Endothelial Barrier
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Protein Localization To Cell Cortex
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Organelle Assembly
Terminal Web Assembly
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
Immunological Synapse Formation
Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Protein Dephosphorylation
Actin Filament Organization
Establishment Or Maintenance Of Cell Polarity
Chemical Synaptic Transmission
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Embryo Development
Viral Process
Peristalsis
Positive Regulation Of Actin Filament Polymerization
Cortical Actin Cytoskeleton Organization
Astral Microtubule Organization
Membrane Raft Organization
Regulation Of Myelination
Activation Of Protein Kinase Activity
Cellular Protein-containing Complex Localization
T Cell Activation
Negative Regulation Of T Cell Proliferation
Regulation Of Membrane Potential
Amyloid Precursor Protein Metabolic Process
Receptor Clustering
Positive Regulation Of Potassium Ion Transport
Cortical Microtubule Organization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
GMP Metabolic Process
GDP Metabolic Process
Reproductive Structure Development
Embryonic Skeletal System Morphogenesis
Smooth Muscle Tissue Development
Negative Regulation Of Epithelial Cell Proliferation
Establishment Of Centrosome Localization
Negative Regulation Of Protein Kinase B Signaling
Hard Palate Development
Negative Regulation Of ERK1 And ERK2 Cascade
Bicellular Tight Junction Assembly
Protein Localization To Plasma Membrane
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Maintenance Of Postsynaptic Density Structure
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Protein Localization To Synapse
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of Potassium Ion Import
Negative Regulation Of P38MAPK Cascade
Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of NMDA Receptor Activity
Pathways
Netrin-1 signaling
Recycling pathway of L1
Recycling pathway of L1
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Diseases
GWAS
Bladder cancer (smoking interaction) (
24662972
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Hair color (
29662168
)
Refractive error (
32231278
)
Allergic rhinitis (
25085501
)
Diastolic blood pressure (
30224653
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Interacting Genes
55 interacting genes:
ACTB
ACTC1
ADORA2B
ADRA1B
ARF6
ARHGDIB
CD44
CDH1
CDK5
CFTR
CLIC5
CTNNB1
DLG1
EGFR
ERBB3
FAS
FASLG
GZMM
ICAM1
ICAM2
ICAM3
IQGAP1
L1CAM
LCK
MDM2
MISP
MME
MPP3
MSN
NF2
PALLD
PIK3R1
PRKAR2A
PRKCA
PTK2
PTPRC
RDX
ROCK1
S100P
SCYL3
SDC2
SELL
SELP
SLC9A3R1
SLC9A3R2
SPN
SUMO2
TBC1D10A
TMEM8B
TSC1
USP1
VCAM1
VPS11
WFDC1
WWOX
75 interacting genes:
ACTA1
ACTN2
ADAM17
ADGRA2
ADGRA3
ADGRB1
ADRB1
AKAP5
ATP2B2
ATP2B4
BCR
BEGAIN
CACNG2
CALM2
CAMK2A
CASK
CNKSR2
CRHR1
CRIPT
CTNNA1
DLG2
DLG3
DLGAP1
DLGAP3
DLGAP4
EPB41
ERBB4
EZR
FZD4
FZD7
GDA
GLS2
GNG13
GRIA1
GRIK2
GRIN1
GRIN2A
GRIN2B
GUCY1A2
HTR2A
KCNA1
KCNA2
KCNA3
KCNA4
KCNA5
KCNAB1
KCNJ10
KCNJ12
KCNJ2
KCNJ4
KCNJ6
KHDRBS1
KIF13B
KIF1B
LCK
LRP2
LRRC1
MAP1A
MAPK12
MPP2
MRPS34
MYO6
PAX6
PBK
PRKN
PTEN
SCN4A
SCN5A
SEMA4C
STX4
TANC1
TJAP1
UBE3A
WAS
WNT3A
Entrez ID
7430
1739
HPRD ID
00475
03007
Ensembl ID
ENSG00000092820
ENSG00000075711
Uniprot IDs
P15311
A0A0C4DFT3
A0A590UJ08
B4DF78
Q12959
PDB IDs
1NI2
4RM8
4RM9
4RMA
1PDR
2M3M
2OQS
2X7Z
3LRA
3RL7
3RL8
3W9Y
4AMH
4G69
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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