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DLG1 and GRIA1
Data Source:
BioGRID
(fluorescent resonance energy transfer, affinity chromatography technology, affinity chromatography technology)
HPRD
(in vitro, in vivo)
DLG1
GRIA1
Description
discs large MAGUK scaffold protein 1
glutamate ionotropic receptor AMPA type subunit 1
Image
No pdb structure
GO Annotations
Cellular Component
Immunological Synapse
Basement Membrane
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Microtubule
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Ionotropic Glutamate Receptor Complex
Cytoplasmic Side Of Plasma Membrane
Intercalated Disc
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Cell Junction
Cell Projection Membrane
Neuromuscular Junction
Node Of Ranvier
Myelin Sheath Abaxonal Region
Sarcolemma
Neuron Projection
Lateral Loop
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
MPP7-DLG1-LIN7 Complex
Synaptic Membrane
Postsynaptic Density Membrane
Glutamatergic Synapse
Golgi Membrane
Endoplasmic Reticulum Membrane
Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Postsynaptic Density
Dendrite
Endocytic Vesicle Membrane
Synaptic Vesicle Membrane
Early Endosome Membrane
AMPA Glutamate Receptor Complex
Dendritic Spine Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Neuronal Cell Body
Dendritic Spine
Axonal Spine
Neuron Spine
Recycling Endosome
Recycling Endosome Membrane
Excitatory Synapse
Synaptic Membrane
Glutamatergic Synapse
Integral Component Of Postsynaptic Density Membrane
Perisynaptic Space
Molecular Function
Guanylate Kinase Activity
Phosphoprotein Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Cytoskeletal Protein Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Binding
Ion Channel Binding
Cadherin Binding
Molecular Adaptor Activity
L27 Domain Binding
Structural Constituent Of Postsynaptic Density
Amyloid-beta Binding
AMPA Glutamate Receptor Activity
Protein Binding
Glutamate Receptor Activity
Ligand-gated Ion Channel Activity
PDZ Domain Binding
Signaling Receptor Activity
Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
Immunological Synapse Formation
Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Protein Dephosphorylation
Actin Filament Organization
Establishment Or Maintenance Of Cell Polarity
Chemical Synaptic Transmission
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Embryo Development
Viral Process
Peristalsis
Positive Regulation Of Actin Filament Polymerization
Cortical Actin Cytoskeleton Organization
Astral Microtubule Organization
Membrane Raft Organization
Regulation Of Myelination
Activation Of Protein Kinase Activity
Cellular Protein-containing Complex Localization
T Cell Activation
Negative Regulation Of T Cell Proliferation
Regulation Of Membrane Potential
Amyloid Precursor Protein Metabolic Process
Receptor Clustering
Positive Regulation Of Potassium Ion Transport
Cortical Microtubule Organization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
GMP Metabolic Process
GDP Metabolic Process
Reproductive Structure Development
Embryonic Skeletal System Morphogenesis
Smooth Muscle Tissue Development
Negative Regulation Of Epithelial Cell Proliferation
Establishment Of Centrosome Localization
Negative Regulation Of Protein Kinase B Signaling
Hard Palate Development
Negative Regulation Of ERK1 And ERK2 Cascade
Bicellular Tight Junction Assembly
Protein Localization To Plasma Membrane
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Maintenance Of Postsynaptic Density Structure
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Protein Localization To Synapse
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of Potassium Ion Import
Negative Regulation Of P38MAPK Cascade
Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of NMDA Receptor Activity
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Signal Transduction
Chemical Synaptic Transmission
Long-term Memory
Receptor Internalization
Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
COPII Vesicle Coating
Regulation Of Postsynaptic Membrane Potential
Long-term Synaptic Depression
Cellular Response To Ammonium Ion
Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Regulation Of NMDA Receptor Activity
Pathways
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
COPII-mediated vesicle transport
Activation of AMPA receptors
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Cargo concentration in the ER
Synaptic adhesion-like molecules
Long-term potentiation
Drugs
Glutamic acid
Butabarbital
Lamotrigine
Isoflurane
Ethanol
Methoxyflurane
Desflurane
Sevoflurane
Talampanel
CX-717
CX516
Perampanel
Tianeptine
Fluciclovine (18F)
Diseases
GWAS
Allergic rhinitis (
25085501
)
Diastolic blood pressure (
30224653
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Adult body size (
32376654
)
Aging (time to event) (
21782286
)
Anthropometric traits (
19260139
)
Asparaginase hypersensitivity in acute lymphoblastic leukemia (
20592726
)
Chronotype (
30696823
)
General risk tolerance (MTAG) (
30643258
)
Hand grip strength (
29691431
)
HDL cholesterol levels (
32203549
)
Interleukin-6 levels (
22205395
)
Middle childhood and early adolescence aggressive behavior (
26087016
)
Morning person (
30696823
)
Obesity-related traits (
23251661
)
Post bronchodilator FEV1 in COPD (
26634245
)
Schizophrenia (
28991256
25056061
30285260
23974872
)
Sudden cardiac arrest (
21658281
)
Survival in microsatellite instability low/stable colorectal cancer (
25866641
)
Interacting Genes
75 interacting genes:
ACTA1
ACTN2
ADAM17
ADGRA2
ADGRA3
ADGRB1
ADRB1
AKAP5
ATP2B2
ATP2B4
BCR
BEGAIN
CACNG2
CALM2
CAMK2A
CASK
CNKSR2
CRHR1
CRIPT
CTNNA1
DLG2
DLG3
DLGAP1
DLGAP3
DLGAP4
EPB41
ERBB4
EZR
FZD4
FZD7
GDA
GLS2
GNG13
GRIA1
GRIK2
GRIN1
GRIN2A
GRIN2B
GUCY1A2
HTR2A
KCNA1
KCNA2
KCNA3
KCNA4
KCNA5
KCNAB1
KCNJ10
KCNJ12
KCNJ2
KCNJ4
KCNJ6
KHDRBS1
KIF13B
KIF1B
LCK
LRP2
LRRC1
MAP1A
MAPK12
MPP2
MRPS34
MYO6
PAX6
PBK
PRKN
PTEN
SCN4A
SCN5A
SEMA4C
STX4
TANC1
TJAP1
UBE3A
WAS
WNT3A
26 interacting genes:
CACNG2
CAMK2A
CAMK2G
CANX
CASP8
CXCR2
DLG1
EPB41L1
EPB41L2
GRIA4
GRID2
GRIK2
GRIP1
GRIPAP1
HOMER1
HSPA5
NEDD4L
PICK1
PRKACA
PRKCA
RPS6KB1
SDCBP
SQSTM1
TANC1
TRPC1
USP46
Entrez ID
1739
2890
HPRD ID
03007
00695
Ensembl ID
ENSG00000075711
ENSG00000155511
Uniprot IDs
A0A0C4DFT3
A0A590UJ08
B4DF78
Q12959
P42261
Q59GL5
PDB IDs
1PDR
2M3M
2OQS
2X7Z
3LRA
3RL7
3RL8
3W9Y
4AMH
4G69
Enriched GO Terms of Interacting Partners
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