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EZR and FAS
Data Source:
BioGRID
(biochemical)
HPRD
(in vitro, in vivo)
EZR
FAS
Description
ezrin
Fas cell surface death receptor
Image
GO Annotations
Cellular Component
Fibrillar Center
Ruffle
Immunological Synapse
Uropod
Extracellular Space
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Brush Border
Focal Adhesion
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Extrinsic Component Of Membrane
Filopodium
T-tubule
Cortical Cytoskeleton
Microvillus Membrane
Vesicle
Ruffle Membrane
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Cell Body
Microspike
Plasma Membrane Raft
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cell Tip
Extracellular Exosome
Cell Periphery
Astrocyte Projection
Schwann Cell Microvillus
Cytoplasmic Side Of Apical Plasma Membrane
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Nuclear Body
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Membrane Raft
Extracellular Exosome
Molecular Function
RNA Binding
Actin Binding
Protein Binding
Microtubule Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Kinase A Catalytic Subunit Binding
Protein Kinase A Regulatory Subunit Binding
Identical Protein Binding
S100 Protein Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Protein Kinase A Binding
ATPase Binding
Disordered Domain Specific Binding
Tumor Necrosis Factor-activated Receptor Activity
Protein Binding
Calmodulin Binding
Kinase Binding
Signaling Receptor Activity
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Intestinal D-glucose Absorption
Sphingosine-1-phosphate Receptor Signaling Pathway
Leukocyte Cell-cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Regulation Of Cell Size
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Gland Morphogenesis
Membrane To Membrane Docking
Microvillus Assembly
Astral Microtubule Organization
Actin Cytoskeleton Reorganization
Receptor Internalization
Regulation Of Microvillus Length
Negative Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Protein-containing Complex Localization
Positive Regulation Of Multicellular Organism Growth
Cortical Microtubule Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Filopodium Assembly
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Protein Secretion
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Establishment Of Centrosome Localization
Establishment Of Endothelial Barrier
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Protein Localization To Cell Cortex
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Organelle Assembly
Terminal Web Assembly
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation-induced Cell Death Of T Cells
Immune Response
Signal Transduction
Regulation Of Stress-activated MAPK Cascade
Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Amino Acid Starvation
Fas Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Protein-containing Complex Assembly
Cellular Response To Mechanical Stimulus
Cellular Response To Hyperoxia
Motor Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways
Netrin-1 signaling
Recycling pathway of L1
Recycling pathway of L1
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TP53 Regulates Transcription of Death Receptors and Ligands
Dimerization of procaspase-8
FasL/ CD95L signaling
Drugs
Diseases
Hodgkin lymphoma
Esophageal cancer
Chronic lymphocytic leukemia (CLL)
Adult T-cell leukemia
GWAS
Bladder cancer (smoking interaction) (
24662972
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Hair color (
29662168
)
Refractive error (
32231278
)
Ankylosing spondylitis (
30946743
)
Atrioventricular conduction (
21041692
)
Blood protein levels (
30072576
29875488
)
Blood protein levels in cardiovascular risk (
28369058
)
Chronic lymphocytic leukemia (
28165464
26956414
24292274
23770605
)
Immunoglobulin A (
20694011
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Mosquito bite size (
28199695
)
Obesity-related traits (
23251661
)
Red blood cell count (
32888494
)
Selective IgA deficiency (
27723758
)
Interacting Genes
55 interacting genes:
ACTB
ACTC1
ADORA2B
ADRA1B
ARF6
ARHGDIB
CD44
CDH1
CDK5
CFTR
CLIC5
CTNNB1
DLG1
EGFR
ERBB3
FAS
FASLG
GZMM
ICAM1
ICAM2
ICAM3
IQGAP1
L1CAM
LCK
MDM2
MISP
MME
MPP3
MSN
NF2
PALLD
PIK3R1
PRKAR2A
PRKCA
PTK2
PTPRC
RDX
ROCK1
S100P
SCYL3
SDC2
SELL
SELP
SLC9A3R1
SLC9A3R2
SPN
SUMO2
TBC1D10A
TMEM8B
TSC1
USP1
VCAM1
VPS11
WFDC1
WWOX
50 interacting genes:
ANK3
APAF1
APOA5
ATP6V0B
BAG6
BTK
CALM1
CASP8
CASP8AP2
CCND3
CD47
CRMP1
DAXX
DNAJC5
EEF1A1
EGFR
ERG28
EZR
FADD
FAF1
FAF2
FAIM2
FASLG
FBF1
FEM1B
FYN
GADD45A
HIPK3
HNRNPC
KRIT1
LCK
LRIF1
MBD4
MET
PDCD6
PRKCA
PTPN13
PTPN6
RAP1A
RIPK1
SUMO1
TCAP
TMX1
TNFSF13
TRADD
TRAF3
TRIP6
UBA7
UBE2I
UBQLN1
Entrez ID
7430
355
HPRD ID
00475
00609
Ensembl ID
ENSG00000092820
ENSG00000026103
Uniprot IDs
P15311
K9J972
P25445
Q59FU8
PDB IDs
1NI2
4RM8
4RM9
4RMA
1BZI
1DDF
2NA7
3EWT
3EZQ
3THM
3TJE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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