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EZR and SLC9A3R1
Data Source:
HPRD
(in vitro, in vivo)
EZR
SLC9A3R1
Description
ezrin
SLC9A3 regulator 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Ruffle
Immunological Synapse
Uropod
Extracellular Space
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Brush Border
Focal Adhesion
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Extrinsic Component Of Membrane
Filopodium
T-tubule
Cortical Cytoskeleton
Microvillus Membrane
Vesicle
Ruffle Membrane
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Cell Body
Microspike
Plasma Membrane Raft
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cell Tip
Extracellular Exosome
Cell Periphery
Astrocyte Projection
Schwann Cell Microvillus
Cytoplasmic Side Of Apical Plasma Membrane
Ruffle
Nucleus
Cytoplasm
Microvillus
Endomembrane System
Actin Cytoskeleton
Membrane
Apical Plasma Membrane
Filopodium
Brush Border Membrane
Microvillus Membrane
Vesicle
Stereocilium Tip
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cell Periphery
Sperm Midpiece
Plasma Membrane Protein Complex
Molecular Function
RNA Binding
Actin Binding
Protein Binding
Microtubule Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Kinase A Catalytic Subunit Binding
Protein Kinase A Regulatory Subunit Binding
Identical Protein Binding
S100 Protein Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Protein Kinase A Binding
ATPase Binding
Disordered Domain Specific Binding
Signaling Receptor Binding
Protein Binding
Beta-catenin Binding
Gamma-aminobutyric Acid Transmembrane Transporter Activity
Chloride Channel Regulator Activity
Phosphatase Binding
PDZ Domain Binding
Beta-2 Adrenergic Receptor Binding
Type 2 Metabotropic Glutamate Receptor Binding
Type 3 Metabotropic Glutamate Receptor Binding
Protein-membrane Adaptor Activity
Protein Self-association
Protein-containing Complex Binding
Myosin II Binding
Protein N-terminus Binding
Dopamine Receptor Binding
Growth Factor Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Intestinal D-glucose Absorption
Sphingosine-1-phosphate Receptor Signaling Pathway
Leukocyte Cell-cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Regulation Of Cell Size
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Gland Morphogenesis
Membrane To Membrane Docking
Microvillus Assembly
Astral Microtubule Organization
Actin Cytoskeleton Reorganization
Receptor Internalization
Regulation Of Microvillus Length
Negative Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Protein-containing Complex Localization
Positive Regulation Of Multicellular Organism Growth
Cortical Microtubule Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Filopodium Assembly
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Protein Secretion
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Establishment Of Centrosome Localization
Establishment Of Endothelial Barrier
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Protein Localization To Cell Cortex
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Organelle Assembly
Terminal Web Assembly
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Early Endosome To Late Endosome Transport
Morphogenesis Of An Epithelium
Renal Sodium Ion Transport
Plasma Membrane Organization
Nuclear Migration
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Cell Size
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Wnt Signaling Pathway
Gland Morphogenesis
Microvillus Assembly
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Cellular Phosphate Ion Homeostasis
Regulation Of Sodium:proton Antiporter Activity
Negative Regulation Of Sodium:proton Antiporter Activity
Bile Acid Secretion
Glutathione Transport
Positive Regulation Of Ion Transmembrane Transport
Regulation Of Excretion
Cilium Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Protein Kinase Activity
Negative Regulation Of Mitotic Cell Cycle
Establishment Of Golgi Localization
Negative Regulation Of Protein Kinase B Signaling
Gamma-aminobutyric Acid Import
Auditory Receptor Cell Stereocilium Organization
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Protein-containing Complex Assembly
Renal Absorption
Negative Regulation Of ERK1 And ERK2 Cascade
Protein Localization To Plasma Membrane
Negative Regulation Of Canonical Wnt Signaling Pathway
Cerebrospinal Fluid Circulation
Renal Phosphate Ion Absorption
Import Across Plasma Membrane
Transport Across Blood-brain Barrier
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Netrin-1 signaling
Recycling pathway of L1
Recycling pathway of L1
Drugs
Diseases
Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS
Bladder cancer (smoking interaction) (
24662972
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Hair color (
29662168
)
Refractive error (
32231278
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Dental caries (decayed and filled deciduous tooth surfaces) (
31533690
)
Fibrinogen (
20031577
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
55 interacting genes:
ACTB
ACTC1
ADORA2B
ADRA1B
ARF6
ARHGDIB
CD44
CDH1
CDK5
CFTR
CLIC5
CTNNB1
DLG1
EGFR
ERBB3
FAS
FASLG
GZMM
ICAM1
ICAM2
ICAM3
IQGAP1
L1CAM
LCK
MDM2
MISP
MME
MPP3
MSN
NF2
PALLD
PIK3R1
PRKAR2A
PRKCA
PTK2
PTPRC
RDX
ROCK1
S100P
SCYL3
SDC2
SELL
SELP
SLC9A3R1
SLC9A3R2
SPN
SUMO2
TBC1D10A
TMEM8B
TSC1
USP1
VCAM1
VPS11
WFDC1
WWOX
61 interacting genes:
ABCC2
ABCC4
ADRB2
AKAP10
AKT1
APPBP2
ATP6V1B1
ATP6V1E1
BCL10
BCL2A1
CFTR
CLCN3
CNGA2
CRABP1
CTNNB1
DLGAP4
EGFR
EZR
GNA11
GNAQ
GRK6
KCNJ1
LHCGR
LPAR2
MSN
NF2
NOS2
OPRK1
P2RY1
PAG1
PDGFRA
PDGFRB
PDZK1
PHLPP1
PLCB1
PLCB2
PRKCA
PTEN
PTH1R
RDX
RLBP1
SCN4A
SKP2
SLC13A1
SLC22A11
SLC22A4
SLC22A5
SLC22A9
SLC26A3
SLC34A1
SLC4A7
SLC4A8
SLC9A3
SLCO1A2
SLCO3A1
TBC1D10A
TRPC4
TRPC5
YAP1
YES1
ZNF468
Entrez ID
7430
9368
HPRD ID
00475
05406
Ensembl ID
ENSG00000092820
ENSG00000109062
Uniprot IDs
P15311
O14745
PDB IDs
1NI2
4RM8
4RM9
4RMA
1G9O
1GQ4
1GQ5
1I92
1SGH
2D10
2JXO
2KJD
2KRG
2M0T
2M0U
2M0V
2OZF
4JL7
4LMM
4MPA
4N6X
4PQW
4Q3H
6RQR
Enriched GO Terms of Interacting Partners
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