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DLG1 and LRP2
Data Source:
HPRD
(two hybrid, in vitro)
DLG1
LRP2
Description
discs large MAGUK scaffold protein 1
LDL receptor related protein 2
Image
GO Annotations
Cellular Component
Immunological Synapse
Basement Membrane
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Microtubule
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Ionotropic Glutamate Receptor Complex
Cytoplasmic Side Of Plasma Membrane
Intercalated Disc
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Cell Junction
Cell Projection Membrane
Neuromuscular Junction
Node Of Ranvier
Myelin Sheath Abaxonal Region
Sarcolemma
Neuron Projection
Lateral Loop
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
MPP7-DLG1-LIN7 Complex
Synaptic Membrane
Postsynaptic Density Membrane
Glutamatergic Synapse
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Clathrin-coated Pit
External Side Of Plasma Membrane
Integral Component Of Membrane
Apical Plasma Membrane
Endocytic Vesicle
Axon
Dendrite
Clathrin-coated Vesicle Membrane
Brush Border Membrane
Endosome Lumen
Receptor Complex
Extracellular Exosome
Molecular Function
Guanylate Kinase Activity
Phosphoprotein Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Cytoskeletal Protein Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Binding
Ion Channel Binding
Cadherin Binding
Molecular Adaptor Activity
L27 Domain Binding
Structural Constituent Of Postsynaptic Density
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Insulin-like Growth Factor I Binding
Hormone Binding
Chaperone Binding
Protein Transporter Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
Immunological Synapse Formation
Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Protein Dephosphorylation
Actin Filament Organization
Establishment Or Maintenance Of Cell Polarity
Chemical Synaptic Transmission
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Embryo Development
Viral Process
Peristalsis
Positive Regulation Of Actin Filament Polymerization
Cortical Actin Cytoskeleton Organization
Astral Microtubule Organization
Membrane Raft Organization
Regulation Of Myelination
Activation Of Protein Kinase Activity
Cellular Protein-containing Complex Localization
T Cell Activation
Negative Regulation Of T Cell Proliferation
Regulation Of Membrane Potential
Amyloid Precursor Protein Metabolic Process
Receptor Clustering
Positive Regulation Of Potassium Ion Transport
Cortical Microtubule Organization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
GMP Metabolic Process
GDP Metabolic Process
Reproductive Structure Development
Embryonic Skeletal System Morphogenesis
Smooth Muscle Tissue Development
Negative Regulation Of Epithelial Cell Proliferation
Establishment Of Centrosome Localization
Negative Regulation Of Protein Kinase B Signaling
Hard Palate Development
Negative Regulation Of ERK1 And ERK2 Cascade
Bicellular Tight Junction Assembly
Protein Localization To Plasma Membrane
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Maintenance Of Postsynaptic Density Structure
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Protein Localization To Synapse
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of Potassium Ion Import
Negative Regulation Of P38MAPK Cascade
Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of NMDA Receptor Activity
Retinoid Metabolic Process
Kidney Development
Neural Tube Closure
Secondary Heart Field Specification
Outflow Tract Septum Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Ventricular Septum Development
Lipid Metabolic Process
Endocytosis
Receptor-mediated Endocytosis
Sensory Perception Of Sound
Cell Population Proliferation
Male Gonad Development
Protein Transport
Metal Ion Transport
Negative Regulation Of BMP Signaling Pathway
Forebrain Development
Aorta Development
Vitamin D Metabolic Process
Negative Regulation Of Apoptotic Process
Response To Leptin
Transcytosis
Positive Regulation Of Neurogenesis
Positive Regulation Of Protein Kinase B Signaling
Vagina Development
Coronary Artery Morphogenesis
Membrane Organization
Pulmonary Artery Morphogenesis
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Cellular Response To Growth Factor Stimulus
Amyloid-beta Clearance
Neuron Projection Arborization
Transport Across Blood-brain Barrier
Folate Import Across Plasma Membrane
Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Vitamin D (calciferol) metabolism
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Retinoid metabolism and transport
Drugs
Urokinase
Insulin pork
Gentamicin
Diseases
Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS
Allergic rhinitis (
25085501
)
Diastolic blood pressure (
30224653
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Anorexia nervosa (
21079607
)
Blood pressure (smoking interaction) (
25189868
)
Chronic kidney disease (
29124443
)
Creatinine levels (
29124443
29403010
)
Estimated glomerular filtration rate (
31152163
31015462
31451708
29779033
29124443
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Hyperuricemia (
29124443
)
Macular thickness (
30535121
)
Optic disc size (
31809533
)
Proteinuria (
30476138
)
Proteinuria (mild) (
30476138
)
Proteinuria (moderate to severe) (
30476138
)
Relapse in multiple sclerosis (
28739605
)
Serum creatinine levels (
29779033
)
Serum uric acid levels (
30993211
29124443
29403010
)
Urate levels (
31578528
20139978
)
Interacting Genes
75 interacting genes:
ACTA1
ACTN2
ADAM17
ADGRA2
ADGRA3
ADGRB1
ADRB1
AKAP5
ATP2B2
ATP2B4
BCR
BEGAIN
CACNG2
CALM2
CAMK2A
CASK
CNKSR2
CRHR1
CRIPT
CTNNA1
DLG2
DLG3
DLGAP1
DLGAP3
DLGAP4
EPB41
ERBB4
EZR
FZD4
FZD7
GDA
GLS2
GNG13
GRIA1
GRIK2
GRIN1
GRIN2A
GRIN2B
GUCY1A2
HTR2A
KCNA1
KCNA2
KCNA3
KCNA4
KCNA5
KCNAB1
KCNJ10
KCNJ12
KCNJ2
KCNJ4
KCNJ6
KHDRBS1
KIF13B
KIF1B
LCK
LRP2
LRRC1
MAP1A
MAPK12
MPP2
MRPS34
MYO6
PAX6
PBK
PRKN
PTEN
SCN4A
SCN5A
SEMA4C
STX4
TANC1
TJAP1
UBE3A
WAS
WNT3A
51 interacting genes:
ALB
ANAPC10
ANKRA2
ANKS1B
APBA2
APBB1
APOB
APOE
APOH
APP
ATN1
CDC42
CLU
CUBN
DAB1
DAB2
DLG1
DLG2
DLG3
DLG4
GC
GIPC1
GPRASP1
INS
ITGB1BP1
LCN2
LDLRAP1
LPA
LPL
LRP2BP
LRPAP1
MAGI1
MAPK8IP1
MAPK8IP2
MDK
NOS1AP
PIP5K1C
PLAU
RAC1
RBP1
RHOA
SCGB1A1
SCN3A
SERPINE1
SLC9A3
SNX17
SYNJ2BP
TG
THBS1
TLN1
TTR
Entrez ID
1739
4036
HPRD ID
03007
02509
Ensembl ID
ENSG00000075711
ENSG00000081479
Uniprot IDs
A0A0C4DFT3
A0A590UJ08
B4DF78
Q12959
P98164
Q7Z5C0
Q7Z5C1
PDB IDs
1PDR
2M3M
2OQS
2X7Z
3LRA
3RL7
3RL8
3W9Y
4AMH
4G69
2M0P
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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