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EZR and IQGAP1
Data Source:
BioGRID
(pull down)
EZR
IQGAP1
Description
ezrin
IQ motif containing GTPase activating protein 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Ruffle
Immunological Synapse
Uropod
Extracellular Space
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Brush Border
Focal Adhesion
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Extrinsic Component Of Membrane
Filopodium
T-tubule
Cortical Cytoskeleton
Microvillus Membrane
Vesicle
Ruffle Membrane
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Cell Body
Microspike
Plasma Membrane Raft
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cell Tip
Extracellular Exosome
Cell Periphery
Astrocyte Projection
Schwann Cell Microvillus
Cytoplasmic Side Of Apical Plasma Membrane
Ruffle
Nucleus
Cytoplasm
Cytosol
Microtubule
Actin Filament
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Microtubule Cytoskeleton
Axon
Growth Cone
Midbody
Secretory Granule Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Protein-containing Complex
Slit Diaphragm
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Membrane Raft
Extracellular Exosome
Molecular Function
RNA Binding
Actin Binding
Protein Binding
Microtubule Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Kinase A Catalytic Subunit Binding
Protein Kinase A Regulatory Subunit Binding
Identical Protein Binding
S100 Protein Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Protein Kinase A Binding
ATPase Binding
Disordered Domain Specific Binding
MAP-kinase Scaffold Activity
GTPase Inhibitor Activity
GTPase Activator Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Small GTPase Binding
Protein Serine/threonine Kinase Activator Activity
S100 Protein Binding
Cadherin Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Molecular Adaptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Intestinal D-glucose Absorption
Sphingosine-1-phosphate Receptor Signaling Pathway
Leukocyte Cell-cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Regulation Of Cell Size
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Gland Morphogenesis
Membrane To Membrane Docking
Microvillus Assembly
Astral Microtubule Organization
Actin Cytoskeleton Reorganization
Receptor Internalization
Regulation Of Microvillus Length
Negative Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Protein-containing Complex Localization
Positive Regulation Of Multicellular Organism Growth
Cortical Microtubule Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Filopodium Assembly
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Protein Secretion
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Establishment Of Centrosome Localization
Establishment Of Endothelial Barrier
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Protein Localization To Cell Cortex
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Organelle Assembly
Terminal Web Assembly
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Early Endosome To Late Endosome Transport
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Mitotic Cell Cycle
Viral Process
Cell Migration
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of GTPase Activity
Neutrophil Degranulation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Focal Adhesion Assembly
Cellular Response To Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Glomerular Visceral Epithelial Cell Development
Positive Regulation Of Dendrite Development
Positive Regulation Of Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cellular Protein Localization
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Neuron Projection Extension
Response To Angiotensin
Pathways
Netrin-1 signaling
Recycling pathway of L1
Recycling pathway of L1
Nephrin family interactions
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
RHO GTPases activate IQGAPs
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Artenimol
Diseases
GWAS
Bladder cancer (smoking interaction) (
24662972
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Hair color (
29662168
)
Refractive error (
32231278
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
31361310
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Chronic postoperative pain (
31903573
)
Heel bone mineral density (
30598549
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Male-pattern baldness (
28196072
)
Monocyte count (
32888494
)
Multiple sclerosis (
24076602
)
Neutrophil percentage of white cells (
32888494
)
Red cell distribution width (
32888494
)
Rheumatoid arthritis (
32868391
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
55 interacting genes:
ACTB
ACTC1
ADORA2B
ADRA1B
ARF6
ARHGDIB
CD44
CDH1
CDK5
CFTR
CLIC5
CTNNB1
DLG1
EGFR
ERBB3
FAS
FASLG
GZMM
ICAM1
ICAM2
ICAM3
IQGAP1
L1CAM
LCK
MDM2
MISP
MME
MPP3
MSN
NF2
PALLD
PIK3R1
PRKAR2A
PRKCA
PTK2
PTPRC
RDX
ROCK1
S100P
SCYL3
SDC2
SELL
SELP
SLC9A3R1
SLC9A3R2
SPN
SUMO2
TBC1D10A
TMEM8B
TSC1
USP1
VCAM1
VPS11
WFDC1
WWOX
38 interacting genes:
ACTA1
AIMP1
AKAP5
APC
CALM1
CDC42
CDH1
CLIC5
CLIP1
CTNNB1
CYBB
DUX4
EGFR
EZR
GRIA4
ILF2
KDR
LBX1
MAPK1
MEI4
MEN1
MEOX2
MYL1
NPHS1
OTX2
PDLIM7
PKNOX2
PRKACA
PTPRM
RAC1
S100B
STAU1
SUMO2
TEPSIN
TSG101
UBE2I
VASP
YWHAQ
Entrez ID
7430
8826
HPRD ID
00475
04541
Ensembl ID
ENSG00000092820
ENSG00000140575
Uniprot IDs
P15311
A0A024RC65
P46940
PDB IDs
1NI2
4RM8
4RM9
4RMA
1X0H
2RR8
3FAY
3I6X
5L0O
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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