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DLG1 and LCK
Data Source:
BioGRID
(imaging technique)
HPRD
(in vivo, in vitro)
DLG1
LCK
Description
discs large MAGUK scaffold protein 1
LCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Immunological Synapse
Basement Membrane
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Microtubule
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Ionotropic Glutamate Receptor Complex
Cytoplasmic Side Of Plasma Membrane
Intercalated Disc
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Cell Junction
Cell Projection Membrane
Neuromuscular Junction
Node Of Ranvier
Myelin Sheath Abaxonal Region
Sarcolemma
Neuron Projection
Lateral Loop
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
MPP7-DLG1-LIN7 Complex
Synaptic Membrane
Postsynaptic Density Membrane
Glutamatergic Synapse
Pericentriolar Material
Immunological Synapse
Cytosol
Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Membrane Raft
Extracellular Exosome
Molecular Function
Guanylate Kinase Activity
Phosphoprotein Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Cytoskeletal Protein Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Binding
Ion Channel Binding
Cadherin Binding
Molecular Adaptor Activity
L27 Domain Binding
Structural Constituent Of Postsynaptic Density
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
ATPase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
Immunological Synapse Formation
Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Protein Dephosphorylation
Actin Filament Organization
Establishment Or Maintenance Of Cell Polarity
Chemical Synaptic Transmission
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Embryo Development
Viral Process
Peristalsis
Positive Regulation Of Actin Filament Polymerization
Cortical Actin Cytoskeleton Organization
Astral Microtubule Organization
Membrane Raft Organization
Regulation Of Myelination
Activation Of Protein Kinase Activity
Cellular Protein-containing Complex Localization
T Cell Activation
Negative Regulation Of T Cell Proliferation
Regulation Of Membrane Potential
Amyloid Precursor Protein Metabolic Process
Receptor Clustering
Positive Regulation Of Potassium Ion Transport
Cortical Microtubule Organization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
GMP Metabolic Process
GDP Metabolic Process
Reproductive Structure Development
Embryonic Skeletal System Morphogenesis
Smooth Muscle Tissue Development
Negative Regulation Of Epithelial Cell Proliferation
Establishment Of Centrosome Localization
Negative Regulation Of Protein Kinase B Signaling
Hard Palate Development
Negative Regulation Of ERK1 And ERK2 Cascade
Bicellular Tight Junction Assembly
Protein Localization To Plasma Membrane
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Maintenance Of Postsynaptic Density Structure
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Protein Localization To Synapse
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of Potassium Ion Import
Negative Regulation Of P38MAPK Cascade
Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of NMDA Receptor Activity
Protein Phosphorylation
Protein Dephosphorylation
Cellular Zinc Ion Homeostasis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Cell Differentiation
Platelet Activation
T Cell Differentiation
T Cell Costimulation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Response To Drug
Innate Immune Response
Regulation Of Defense Response To Virus By Virus
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Leukocyte Migration
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Lymphocyte Activation
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-2 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Drugs
Dasatinib
AP-22408
Staurosporine
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
{4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid
Phosphoaminophosphonic Acid-Adenylate Ester
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
Ponatinib
Nintedanib
Fostamatinib
Zanubrutinib
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Allergic rhinitis (
25085501
)
Diastolic blood pressure (
30224653
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Multiple sclerosis (
31604244
)
Interacting Genes
75 interacting genes:
ACTA1
ACTN2
ADAM17
ADGRA2
ADGRA3
ADGRB1
ADRB1
AKAP5
ATP2B2
ATP2B4
BCR
BEGAIN
CACNG2
CALM2
CAMK2A
CASK
CNKSR2
CRHR1
CRIPT
CTNNA1
DLG2
DLG3
DLGAP1
DLGAP3
DLGAP4
EPB41
ERBB4
EZR
FZD4
FZD7
GDA
GLS2
GNG13
GRIA1
GRIK2
GRIN1
GRIN2A
GRIN2B
GUCY1A2
HTR2A
KCNA1
KCNA2
KCNA3
KCNA4
KCNA5
KCNAB1
KCNJ10
KCNJ12
KCNJ2
KCNJ4
KCNJ6
KHDRBS1
KIF13B
KIF1B
LCK
LRP2
LRRC1
MAP1A
MAPK12
MPP2
MRPS34
MYO6
PAX6
PBK
PRKN
PTEN
SCN4A
SCN5A
SEMA4C
STX4
TANC1
TJAP1
UBE3A
WAS
WNT3A
143 interacting genes:
ACP1
ADAM15
AJUBA
AR
ARHGAP17
ASB9
AXL
BCAR1
BRCA1
C1QTNF2
CBL
CCR5
CD2
CD247
CD28
CD38
CD3E
CD4
CD44
CD48
CD5
CD55
CD79A
CD79B
CD8A
CDC25C
CDC42
CDC45
CDKAL1
CSF2RB
CSF3R
CSK
CSNK2B
CTDSP1
CTLA4
CTNND1
CTNND2
DAPP1
DEF6
DLG1
DOK1
DOK2
DOK3
EGFR
ERBB2
ERBB3
ERBB4
ESR1
ESR2
EZR
FAM166B
FAM174A
FAS
FASLG
FCGR3A
FYN
G3BP1
GAB1
GAB2
GATA3
GRAP
HSP90AA1
IFNAR1
IKBKG
IL2RB
ITK
JAK3
KHDRBS1
KIR2DL3
KIT
LAT
LAX1
LCP2
LIME1
LZTS2
MAPK1
MAPK3
MAPT
MED28
MET
MS4A1
MUC1
NEDD9
NFKBIA
NFKBID
NOTCH1
NR3C1
PAG1
PAK2
PECAM1
PI4KA
PIK3CA
PIK3R1
PLCG1
PLCG2
PLD2
PRKACA
PRKCA
PRKCD
PRKCQ
PTK2
PTK2B
PTPN11
PTPN22
PTPN6
PTPRC
PTPRF
PTPRH
PXN
RAF1
RASA1
RIN3
RORB
SH2B3
SH2D1A
SH2D2A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SMAD2
SMAD3
SMURF1
SOS1
SQSTM1
STAT1
STAT3
STAT5A
SYK
THY1
TRAT1
TRIM35
TRPV4
TUB
UBAP2
UBE3A
UHRF2
UNC119
VAV1
WAS
WASL
ZAP70
Entrez ID
1739
3932
HPRD ID
03007
01080
Ensembl ID
ENSG00000075711
ENSG00000182866
Uniprot IDs
A0A0C4DFT3
A0A590UJ08
B4DF78
Q12959
A0A0S2Z3Y4
A0A0S2Z3Y8
P06239
Q573B4
PDB IDs
1PDR
2M3M
2OQS
2X7Z
3LRA
3RL7
3RL8
3W9Y
4AMH
4G69
1BHF
1BHH
1CWD
1CWE
1FBZ
1H92
1IJR
1KIK
1LCJ
1LCK
1LKK
1LKL
1Q68
1Q69
1QPC
1QPD
1QPE
1QPJ
1X27
2IIM
2OF2
2OF4
2OFU
2OFV
2OG8
2PL0
2ZM1
2ZM4
2ZYB
3AC1
3AC2
3AC3
3AC4
3AC5
3AC8
3ACJ
3ACK
3AD4
3AD5
3AD6
3B2W
3BRH
3BYM
3BYO
3BYS
3BYU
3KMM
3KXZ
3LCK
3MPM
4C3F
4D8K
5MTM
5MTN
6H6A
6PDJ
Enriched GO Terms of Interacting Partners
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