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ZNF417 and SPRED1
Data Source:
BioGRID
(two hybrid)
ZNF417
SPRED1
Description
zinc finger protein 417
sprouty related EVH1 domain containing 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Caveola
Cytoplasmic Vesicle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Stem Cell Factor Receptor Binding
Protein Binding
Protein Kinase Binding
Phosphatase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Inactivation Of MAPK Activity
Negative Regulation Of Protein Kinase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Phosphatase Activity
Negative Regulation Of Angiogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of MAPK Cascade
Negative Regulation Of MAPK Cascade
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Vasculogenesis Involved In Coronary Vascular Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Protein Deacetylation
Negative Regulation Of Lens Fiber Cell Differentiation
Pathways
Generic Transcription Pathway
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling
RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Depression in smokers (
30219690
)
Bipolar disorder (
20351715
)
Birth weight (
31043758
)
Cognitive performance (processing speed) (
31598132
)
Crohn's disease (
23128233
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Erosive tooth wear (severe vs none or mild) (
29898447
)
HDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
Hypersomnia (HLA-DQB1*06:02 negative) (
23646285
)
Interacting Genes
169 interacting genes:
ADAMTSL4
AXIN2
BEGAIN
BEND5
BEX3
BHLHB9
BICD2
C4orf17
CARD9
CBY2
CCDC125
CCDC136
CCDC57
CCDC85B
CCNDBP1
CDR2
CDR2L
CEP44
CEP70
CEP72
CEP85L
CHRDL2
COG6
CSRNP1
CYSRT1
DEF8
DVL3
EFS
EZHIP
FAM221A
FHL2
FHL3
FHL5
FRS3
FSD2
FXR1
GOLGA2
GOLGA6L9
HMBOX1
HOMEZ
HOOK2
HOXA1
HSF2BP
IGFBP6
IHO1
IKZF1
INKA1
JADE2
JRK
KAT5
KATNBL1
KCTD7
KIF9
KIFC3
KLC3
KRT15
KRT31
KRT35
KRT38
KRT39
KRT40
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-9
KXD1
LHX3
LIMS1
LMO1
LURAP1
LZTS1
LZTS2
MAGEA8
MAST2
MCC
MCCD1
MDFI
MEIS3
MEOX2
MID2
MIIP
MRFAP1L1
MTUS2
MYF5
MYLIP
NAB2
NBPF19
NDEL1
NDUFB7
NINL
NKAPL
NKX3-1
NOTCH2NLA
OIP5
PHC2
PICK1
PIH1D2
PLSCR1
PNMA2
PRICKLE4
PRPF31
RCN3
REL
RHOQ
RNF187
RORB
RPGRIP1
RUNDC3A
SH2B2
SMARCD1
SMYD5
SPRED1
SPRED2
SPRY1
SPRY2
SSX2IP
STX11
SUV39H1
TADA2A
TCF4
TEKT4
TFIP11
TLE5
TMCC2
TNS2
TRAF1
TRAF2
TRIB3
TRIM23
TRIM27
TRIM36
TRIM37
TRIM41
TRIM54
TSC1
TSGA10
TXNDC11
U2AF1
U2AF1L5
USHBP1
VPS16
VPS52
VWC2
ZBTB1
ZBTB10
ZBTB43
ZBTB8A
ZBTB9
ZNF165
ZNF19
ZNF20
ZNF547
ZNF572
ZNF587
ZNF69
ZNF71
ZNF768
ZNF774
ZNF837
ZNF85
ZRANB1
37 interacting genes:
ANKS1A
AQP1
BEX2
BLZF1
C2orf68
CCDC185
CDKN1A
CREB5
DNAJB11
FAM118B
FAM90A1
GLYCTK
HEXIM2
HPCAL4
HSF2BP
IL16
KIT
MAB21L3
MEOX2
NAGK
NCALD
OSGEP
PIH1D2
PPP1CA
PPP1R7
PRPF18
RCC1
RIN1
SPG21
SUV39H1
TSC22D1
TTC19
VSNL1
ZNF408
ZNF417
ZNF587
ZNF655
Entrez ID
147687
161742
HPRD ID
18341
11601
Ensembl ID
ENSG00000173480
ENSG00000166068
Uniprot IDs
M0R230
Q8TAU3
Q7Z699
PDB IDs
3SYX
6V65
6V6F
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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