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HCK and PECAM1
Data Source:
HPRD
(in vivo, in vitro)
HCK
PECAM1
Description
HCK proto-oncogene, Src family tyrosine kinase
platelet and endothelial cell adhesion molecule 1
Image
GO Annotations
Cellular Component
Nucleus
Lysosome
Golgi Apparatus
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Transport Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Projection
Intracellular Membrane-bounded Organelle
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Secretory Granule Membrane
Platelet Alpha Granule Membrane
Protein-containing Complex
Membrane Raft
Extracellular Exosome
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Transmembrane Signaling Receptor Activity
Protein Binding
Protein Homodimerization Activity
Biological Process
Leukocyte Migration Involved In Immune Response
Innate Immune Response-activating Signal Transduction
Protein Phosphorylation
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Positive Regulation Of Actin Filament Polymerization
Lipopolysaccharide-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Apoptotic Process
Leukocyte Degranulation
Innate Immune Response
Respiratory Burst After Phagocytosis
Protein Autophosphorylation
Regulation Of Defense Response To Virus By Virus
Regulation Of Inflammatory Response
Regulation Of Phagocytosis
Regulation Of DNA-binding Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Podosome Assembly
Positive Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Phagocytosis
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Leukocyte Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Recognition
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Maintenance Of Blood-brain Barrier
Monocyte Extravasation
Neutrophil Degranulation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Diapedesis
Establishment Of Endothelial Barrier
Bicellular Tight Junction Assembly
Glomerular Endothelium Development
Neutrophil Extravasation
Cell-cell Adhesion
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of Protein Localization To Cell-cell Junction
Pathways
Nef and signal transduction
FCGR activation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Platelet degranulation
Cell surface interactions at the vascular wall
PECAM1 interactions
Integrin cell surface interactions
Platelet sensitization by LDL
Neutrophil degranulation
Drugs
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Phosphonotyrosine
Quercetin
Bosutinib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Inflammatory bowel disease (
23128233
)
Migraine (
27322543
)
Coronary artery disease (
32469254
29212778
33020668
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
)
Interacting Genes
116 interacting genes:
ABL1
ABL2
ACTB
ADAM15
AGK
AGR2
APP
AR
ARRB1
ASAP1
BCAR1
BCR
BPIFA1
BTK
CBL
CCDC88B
CCR3
CD2AP
CHST15
CREBBP
CSF2RB
CSF3R
CSK
CTAG1A
CTAG1B
CYB5D2
CYSRT1
DNM2
DOK1
DOK2
EGFR
ELMO1
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCGR1A
FCGR2A
FHL2
FHL5
GAB1
GOPC
GRB14
HNRNPK
HSF2BP
IL6ST
INCA1
INPP5D
IRF2BPL
KHDRBS1
KIT
KPRP
KRT31
KRT34
KRT35
KRT36
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-1
LCP2
LETMD1
LMNA
MAP4K5
MDK
MDM2
MET
MID2
MKRN3
MTUS2
NBPF19
NGEF
NOTCH2NLA
PAK2
PECAM1
PIK3CB
PIK3R1
PIK3R2
PLAUR
PLCG1
PLCG2
PLEKHG4
PNMA1
RAPGEF1
RASA1
RASA3
RBPMS
RPL10
SF3B3
SH2B2
SH3BP1
SH3KBP1
SKAP2
SOS1
SPRR2A
STAT3
TEKT4
TEPSIN
TNK2
TOX2
TP73
TRIM27
TRIP6
TRPV4
TSG101
UNC119
VAV1
WAS
WDCP
WIPF1
WNT2
ZSCAN4
22 interacting genes:
CD38
CSK
CTNNB1
DSP
EFNB2
FYN
HCK
INPP5D
ITGA5
ITGB3
JUP
LCK
LYN
PIK3R1
PLCG1
PRKCE
PRPF40A
PTPN11
PTPN6
SRC
XRCC6
YES1
Entrez ID
3055
5175
HPRD ID
00796
01425
Ensembl ID
ENSG00000101336
ENSG00000261371
Uniprot IDs
A8K4G3
P08631
P16284
PDB IDs
1AD5
1BU1
1QCF
2C0I
2C0O
2C0T
2HCK
2HK5
2OI3
2OJ2
3HCK
3NHN
3RBB
3REA
3REB
3VRY
3VRZ
3VS0
3VS1
3VS2
3VS3
3VS4
3VS5
3VS6
3VS7
4HCK
4LUD
4LUE
4ORZ
4U5W
5H09
5H0B
5H0E
5H0G
5H0H
5HCK
5NUH
5ZJ6
2KY5
5C14
5GNI
Enriched GO Terms of Interacting Partners
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