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HCK and UNC119
Data Source:
HPRD
(in vitro)
HCK
UNC119
Description
HCK proto-oncogene, Src family tyrosine kinase
unc-119 lipid binding chaperone
Image
GO Annotations
Cellular Component
Nucleus
Lysosome
Golgi Apparatus
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Transport Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Projection
Intracellular Membrane-bounded Organelle
Spindle Pole
Centrosome
Cytosol
Intercellular Bridge
Synapse
Spindle Midzone
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein Binding
Lipid Binding
Biological Process
Leukocyte Migration Involved In Immune Response
Innate Immune Response-activating Signal Transduction
Protein Phosphorylation
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Positive Regulation Of Actin Filament Polymerization
Lipopolysaccharide-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Apoptotic Process
Leukocyte Degranulation
Innate Immune Response
Respiratory Burst After Phagocytosis
Protein Autophosphorylation
Regulation Of Defense Response To Virus By Virus
Regulation Of Inflammatory Response
Regulation Of Phagocytosis
Regulation Of DNA-binding Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Podosome Assembly
Positive Regulation Of Actin Cytoskeleton Reorganization
Mitotic Cytokinesis
Endocytosis
Chemical Synaptic Transmission
Nervous System Development
Visual Perception
Phototransduction
Lipoprotein Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Clathrin-dependent Endocytosis
Negative Regulation Of Caveolin-mediated Endocytosis
Pathways
Nef and signal transduction
FCGR activation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Drugs
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Phosphonotyrosine
Quercetin
Bosutinib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Inflammatory bowel disease (
23128233
)
Migraine (
27322543
)
Interacting Genes
116 interacting genes:
ABL1
ABL2
ACTB
ADAM15
AGK
AGR2
APP
AR
ARRB1
ASAP1
BCAR1
BCR
BPIFA1
BTK
CBL
CCDC88B
CCR3
CD2AP
CHST15
CREBBP
CSF2RB
CSF3R
CSK
CTAG1A
CTAG1B
CYB5D2
CYSRT1
DNM2
DOK1
DOK2
EGFR
ELMO1
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCGR1A
FCGR2A
FHL2
FHL5
GAB1
GOPC
GRB14
HNRNPK
HSF2BP
IL6ST
INCA1
INPP5D
IRF2BPL
KHDRBS1
KIT
KPRP
KRT31
KRT34
KRT35
KRT36
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-1
LCP2
LETMD1
LMNA
MAP4K5
MDK
MDM2
MET
MID2
MKRN3
MTUS2
NBPF19
NGEF
NOTCH2NLA
PAK2
PECAM1
PIK3CB
PIK3R1
PIK3R2
PLAUR
PLCG1
PLCG2
PLEKHG4
PNMA1
RAPGEF1
RASA1
RASA3
RBPMS
RPL10
SF3B3
SH2B2
SH3BP1
SH3KBP1
SKAP2
SOS1
SPRR2A
STAT3
TEKT4
TEPSIN
TNK2
TOX2
TP73
TRIM27
TRIP6
TRPV4
TSG101
UNC119
VAV1
WAS
WDCP
WIPF1
WNT2
ZSCAN4
103 interacting genes:
AAGAB
ALDH2
AMOT
ANKRD24
ANXA1
ANXA3
ANXA7
ARL15
ARL2
ARL3
ARL4D
ASH2L
BCR
BRIX1
BTBD2
C16orf74
CBX8
CCL18
CD247
CD3E
CD4
CDC42
CDKN1A
CDKN2C
CETN3
CKMT2
CKS2
COX17
CYB561D2
EIF2S2
ERH
FKBPL
FXYD6
FYN
GIPC2
GSTM4
HCK
HLA-DQA1
HMGB1
HSPB3
HSPE1
ID2
IL5RA
ITSN1
KDM1A
KRTAP1-3
KRTAP9-3
KRTAP9-8
LAMA4
LCK
LIG4
LRIF1
LUC7L2
LYN
MAP3K20
MAPK10
MAPK8IP2
MPHOSPH6
MRPS12
ORAI2
PAFAH1B3
PAPSS1
PCDHA4
PFN1
PHF10
PIN1
PLPP2
PPA1
PPP3CA
PPP3CC
PSMD11
PSMD2
PTPRS
QTRT1
RAP1B
RASSF6
RBPMS2
RCAN3
RCC1
RFC5
RGL2
RPA2
RPS6KA5
RUFY3
S100A4
S100A8
SAT1
SEPHS1
SERPINB9
SMN1
SULT1E1
TK1
TMEM200A
TP53BP2
TP53I3
TP53INP1
TRDMT1
TSC22D1
UBE2B
UBE2I
UBQLN4
ZFP64
ZNF24
Entrez ID
3055
9094
HPRD ID
00796
04927
Ensembl ID
ENSG00000101336
ENSG00000109103
Uniprot IDs
A8K4G3
P08631
K7EN86
Q13432
PDB IDs
1AD5
1BU1
1QCF
2C0I
2C0O
2C0T
2HCK
2HK5
2OI3
2OJ2
3HCK
3NHN
3RBB
3REA
3REB
3VRY
3VRZ
3VS0
3VS1
3VS2
3VS3
3VS4
3VS5
3VS6
3VS7
4HCK
4LUD
4LUE
4ORZ
4U5W
5H09
5H0B
5H0E
5H0G
5H0H
5HCK
5NUH
5ZJ6
3GQQ
3RBQ
4GOJ
4GOK
5L7K
6H6A
Enriched GO Terms of Interacting Partners
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