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HCK and MID2
Data Source:
BioGRID
(two hybrid)
HCK
MID2
Description
HCK proto-oncogene, Src family tyrosine kinase
midline 2
Image
GO Annotations
Cellular Component
Nucleus
Lysosome
Golgi Apparatus
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Transport Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Projection
Intracellular Membrane-bounded Organelle
Cytoplasm
Microtubule
Extracellular Exosome
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Transcription Coactivator Activity
Microtubule Binding
Zinc Ion Binding
Transferase Activity
Enzyme Binding
Protein Homodimerization Activity
Phosphoprotein Binding
Biological Process
Leukocyte Migration Involved In Immune Response
Innate Immune Response-activating Signal Transduction
Protein Phosphorylation
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Positive Regulation Of Actin Filament Polymerization
Lipopolysaccharide-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Apoptotic Process
Leukocyte Degranulation
Innate Immune Response
Respiratory Burst After Phagocytosis
Protein Autophosphorylation
Regulation Of Defense Response To Virus By Virus
Regulation Of Inflammatory Response
Regulation Of Phagocytosis
Regulation Of DNA-binding Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Podosome Assembly
Positive Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Autophagy
Protein Ubiquitination
Negative Regulation Of Viral Transcription
Protein Localization To Microtubule
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Viral Release From Host Cell
Pathways
Nef and signal transduction
FCGR activation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Drugs
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Phosphonotyrosine
Quercetin
Bosutinib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Inflammatory bowel disease (
23128233
)
Migraine (
27322543
)
Interacting Genes
116 interacting genes:
ABL1
ABL2
ACTB
ADAM15
AGK
AGR2
APP
AR
ARRB1
ASAP1
BCAR1
BCR
BPIFA1
BTK
CBL
CCDC88B
CCR3
CD2AP
CHST15
CREBBP
CSF2RB
CSF3R
CSK
CTAG1A
CTAG1B
CYB5D2
CYSRT1
DNM2
DOK1
DOK2
EGFR
ELMO1
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCGR1A
FCGR2A
FHL2
FHL5
GAB1
GOPC
GRB14
HNRNPK
HSF2BP
IL6ST
INCA1
INPP5D
IRF2BPL
KHDRBS1
KIT
KPRP
KRT31
KRT34
KRT35
KRT36
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-1
LCP2
LETMD1
LMNA
MAP4K5
MDK
MDM2
MET
MID2
MKRN3
MTUS2
NBPF19
NGEF
NOTCH2NLA
PAK2
PECAM1
PIK3CB
PIK3R1
PIK3R2
PLAUR
PLCG1
PLCG2
PLEKHG4
PNMA1
RAPGEF1
RASA1
RASA3
RBPMS
RPL10
SF3B3
SH2B2
SH3BP1
SH3KBP1
SKAP2
SOS1
SPRR2A
STAT3
TEKT4
TEPSIN
TNK2
TOX2
TP73
TRIM27
TRIP6
TRPV4
TSG101
UNC119
VAV1
WAS
WDCP
WIPF1
WNT2
ZSCAN4
238 interacting genes:
ADAMTSL4
AEN
ALDH3B1
ANKS1A
AP1M1
AQP1
ARHGEF5
ATRIP
AXIN1
BAHD1
BCL6B
BLK
BLZF1
BRCA1
BRMS1L
BYSL
C1orf35
CALCOCO2
CARD9
CARHSP1
CBX8
CCDC120
CCDC185
CCDC187
CCDC33
CCDC42
CCHCR1
CDK18
CEP57L1
CFP
CHD2
CNNM3
COX5B
CPSF4
CRACR2A
CREBRF
CTSZ
DCX
DGCR6
DGCR6L
DMRT3
DYDC1
EFHC2
EGFL7
EIF1AD
ELOA
ENKD1
EPN2
ETNK2
FAM107A
FAM161A
FAM161B
FAM214A
FAM214B
FAM50B
FAM90A1
FARS2
FASTKD5
FBF1
FBXL18
FBXW5
FOXD4L3
FRMD6
FSD2
GAS2L2
GAS8
GCC1
GEM
GFI1B
GMCL1
GOLGA2
GOLGA7
GORASP2
GPANK1
GPKOW
GSC2
HAPLN2
HCK
HDAC4
HDX
HNRNPLL
HOXB2
HOXB5
HOXB9
IGBP1
IGFN1
IHO1
IKZF3
IL16
INO80B
IQCN
ISCU
ITGB4
JOSD1
KANK2
KIF1A
KIF9
KIFC3
KRT27
KRT31
KRT40
KRT75
KRT76
LAGE3
LENG1
LGALS14
LGALS8
LMNB2
LMNTD2
LMO3
LMO4
LNX1
LONRF1
LRRC45
LZTS1
LZTS2
MAGEA6
MAGOHB
MEOX1
MEOX2
METTL17
MFAP1
MID1
MID1IP1
MOS
MVP
NCOA4
NR1D2
NSMF
NXF1
OTUB2
PICK1
PKN1
POLDIP3
PPP1R18
PRDM16
PRPF3
PRPF31
PSMA1
PTCD2
PTPDC1
QARS1
RABGEF1
RANBP3L
RCOR3
REL
RLN1
RNF6
RORB
RPH3AL
RPP25L
RUNX1T1
RXRB
SCNM1
SDCBP
SEPTIN1
SHFL
SLC25A48
SLC25A6
SNAI1
SNAP47
SPAG5
SPATA24
SPG21
SPRY2
STX11
SYNGAP1
SYT17
TASOR2
TBC1D22B
TCAF1
TCEA2
TCEANC
TEKT1
THAP7
TMEM14B
TOP3B
TRIM27
TRIM29
TRIM32
TRIM41
TRIM42
TRIM54
TRIM69
TRPV6
TSGA10
TTC23
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E2
UBE2E3
UBE2K
UBE2U
UBTD1
UNC45A
USP2
USP25
USP54
UTP23
UTP25
WT1-AS
ZBTB16
ZBTB24
ZBTB42
ZC2HC1C
ZFYVE21
ZGPAT
ZIM2
ZNF124
ZNF165
ZNF177
ZNF24
ZNF250
ZNF266
ZNF408
ZNF410
ZNF417
ZNF438
ZNF440
ZNF451
ZNF497
ZNF552
ZNF559-ZNF177
ZNF564
ZNF587
ZNF648
ZNF669
ZNF688
ZNF696
ZNF764
ZNF774
ZNF784
ZNF785
ZNF792
ZRANB1
ZSCAN12
Entrez ID
3055
11043
HPRD ID
00796
02191
Ensembl ID
ENSG00000101336
ENSG00000080561
Uniprot IDs
A8K4G3
P08631
Q6GX22
Q9UJV3
PDB IDs
1AD5
1BU1
1QCF
2C0I
2C0O
2C0T
2HCK
2HK5
2OI3
2OJ2
3HCK
3NHN
3RBB
3REA
3REB
3VRY
3VRZ
3VS0
3VS1
3VS2
3VS3
3VS4
3VS5
3VS6
3VS7
4HCK
4LUD
4LUE
4ORZ
4U5W
5H09
5H0B
5H0E
5H0G
5H0H
5HCK
5NUH
5ZJ6
2DJA
2DMK
Enriched GO Terms of Interacting Partners
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