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TLR2 and TGFB1
Data Source:
BioGRID
(two hybrid)
TLR2
TGFB1
Description
toll like receptor 2
transforming growth factor beta 1
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Intrinsic Component Of Plasma Membrane
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Cell Projection
Cell Body
Membrane Raft
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Plasma Membrane
Microvillus
Cell Surface
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Blood Microparticle
Molecular Function
Lipopolysaccharide Binding
Amyloid-beta Binding
Lipopolysaccharide Immune Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor Binding
Signaling Receptor Activity
Pattern Recognition Receptor Activity
Triacyl Lipopeptide Binding
Identical Protein Binding
Peptidoglycan Binding
Protein-containing Complex Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Antigen Binding
Type II Transforming Growth Factor Beta Receptor Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Enzyme Binding
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
Biological Process
Response To Hypoxia
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Leukotriene Metabolic Process
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
I-kappaB Phosphorylation
Learning
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Positive Regulation Of Gene Expression
Microglia Development
Positive Regulation Of Wnt Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Central Nervous System Myelin Formation
Response To Progesterone
Interleukin-10 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Insulin
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Triacyl Bacterial Lipopeptide
Detection Of Diacyl Bacterial Lipopeptide
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Nitric Oxide Metabolic Process
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Negative Regulation Of Synapse Assembly
Response To Fatty Acid
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Cellular Response To Interferon-gamma
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Matrix Metallopeptidase Secretion
MAPK Cascade
Vasculogenesis
Epithelial To Mesenchymal Transition
Neural Tube Closure
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Chondrocyte Differentiation
Hematopoietic Progenitor Cell Differentiation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Platelet Degranulation
Heart Valve Morphogenesis
Aortic Valve Morphogenesis
Protein Phosphorylation
Protein Export From Nucleus
ATP Biosynthetic Process
Phosphate-containing Compound Metabolic Process
Inflammatory Response
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
SMAD Protein Complex Assembly
Salivary Gland Morphogenesis
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Wounding
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Macrophage Cytokine Production
Positive Regulation Of Microglia Differentiation
Regulation Of Striated Muscle Tissue Development
Cell Migration
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Neural Tube Development
Negative Regulation Of Cell-cell Adhesion
Hyaluronan Catabolic Process
Negative Regulation Of Cell Growth
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein-containing Complex Assembly
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Response To Estradiol
Response To Progesterone
Positive Regulation Of Interleukin-17 Production
Receptor Catabolic Process
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Protein Dephosphorylation
Regulation Of Cell Population Proliferation
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Vascular Permeability
Positive Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Ossification Involved In Bone Remodeling
Cell-cell Junction Organization
Negative Regulation Of Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Cytolysis
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgA Isotypes
Lymph Node Development
Negative Regulation Of Skeletal Muscle Tissue Development
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Chemotaxis
Regulation Of Binding
Regulation Of DNA Binding
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Blood Vessel Remodeling
Pathway-restricted SMAD Protein Phosphorylation
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Negative Regulation Of Gene Silencing By MiRNA
Negative Regulation Of Biomineral Tissue Development
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Cholesterol
Cellular Response To Organic Cyclic Compound
Cellular Response To Transforming Growth Factor Beta Stimulus
Extracellular Matrix Assembly
Positive Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of NAD+ ADP-ribosyltransferase Activity
Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Heart Development
Embryonic Liver Development
Positive Regulation Of Transcription Regulatory Region DNA Binding
Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Modulation by Mtb of host immune system
Platelet degranulation
Influenza Virus Induced Apoptosis
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Syndecan interactions
ECM proteoglycans
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Transcriptional regulation of white adipocyte differentiation
UCH proteinases
Interleukin-4 and Interleukin-13 signaling
RUNX3 regulates CDKN1A transcription
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
Drugs
Lyme disease vaccine (recombinant OspA)
Adapalene
S-(Dimethylarsenic)Cysteine
Golotimod
Tuberculin purified protein derivative
Hyaluronidase (ovine)
Terazosin
Hyaluronidase (human recombinant)
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Hyaluronidase
Diseases
Graft-versus-host disease
Allograft rejection
Camurati-Engelmann disease; Progressive diaphyseal dysplasia
GWAS
Body fat mass (
28552196
)
Colorectal cancer (
27145994
24836286
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
28714974
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Hematuria (
30476138
)
Hematuria (mild) (
30476138
)
Hematuria (moderate to severe) (
30476138
)
Platelet count (
32888494
)
Preterm birth (maternal effect) (
28877031
)
Pulse pressure (
30578418
)
Type 2 diabetes (
31049640
)
Interacting Genes
29 interacting genes:
AKT1
ANP32B
CD14
EGFR
FBP1
HEMGN
HMGB1
HRAS
HSP90B1
IRAK1
LY96
MAP2K1
MAPK8IP3
MYD88
NANS
PIK3R1
RAC1
RIPK2
SMAD1
STX17
TGFB1
TICAM1
TIRAP
TLR1
TLR10
TLR6
TMOD1
TOLLIP
TRIP6
95 interacting genes:
ACVRL1
ADAMTSL4
AGR3
ANGPTL4
APC
APP
AURKA
AXIN2
BCAS3
BCL10
BGN
BLID
BMP2
BMP3
BMPR1A
BUB1
CATSPER1
CCDC33
CCL3
CCL5
CCN2
CDKN2A
COL2A1
CST6
CYSRT1
DAXX
DCN
DIRAS3
DLC1
DPT
EGFR
EIF3I
ENG
ERBB2
FBXW7
FCHO1
FCN1
FKBP1A
FMOD
FNTA
GREB1
HOXA1
HOXC6
ITGAV
ITGB6
ITGB8
KLK5
KLK7
KLK9
KRTAP1-1
KRTAP1-3
KRTAP10-8
KRTAP4-11
LAMTOR5
LCE1A
LCE1C
LCE1D
LCE2B
LCE2C
LCE3A
LCE3B
LCE3D
LPXN
LTBP1
LTBP3
LTBP4
MCC
MEOX2
MLH3
MMP2
MTA3
NSD3
P4HB
PDGFRL
PDLIM2
POU4F2
PRSS50
PSMC3IP
PZP
RAPGEF3
SCGB3A1
SDC2
SNAI1
SPARC
ST14
TGFB2
TGFBR1
TGFBR2
TGFBR3
THBS1
THRSP
TLR2
VASN
VTN
YWHAE
Entrez ID
7097
7040
HPRD ID
04323
01821
Ensembl ID
ENSG00000137462
ENSG00000105329
Uniprot IDs
A0A0S2Z4S4
B3KWR9
O60603
A0A499FJK2
P01137
PDB IDs
1FYW
1FYX
1O77
2Z7X
2Z80
6NIG
1KLA
1KLC
1KLD
3KFD
4KV5
5FFO
5VQP
6OM2
6P7J
Enriched GO Terms of Interacting Partners
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