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TLR2 and RIPK2
Data Source:
HPRD
(in vivo)
TLR2
RIPK2
Description
toll like receptor 2
receptor interacting serine/threonine kinase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Intrinsic Component Of Plasma Membrane
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Cell Projection
Cell Body
Membrane Raft
Cytoplasm
Cytosol
Cytoskeleton
Vesicle
Protein-containing Complex
Molecular Function
Lipopolysaccharide Binding
Amyloid-beta Binding
Lipopolysaccharide Immune Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor Binding
Signaling Receptor Activity
Pattern Recognition Receptor Activity
Triacyl Lipopeptide Binding
Identical Protein Binding
Peptidoglycan Binding
Protein-containing Complex Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
LIM Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
CARD Domain Binding
Caspase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Response To Hypoxia
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Leukotriene Metabolic Process
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
I-kappaB Phosphorylation
Learning
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Positive Regulation Of Gene Expression
Microglia Development
Positive Regulation Of Wnt Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Central Nervous System Myelin Formation
Response To Progesterone
Interleukin-10 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Insulin
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Triacyl Bacterial Lipopeptide
Detection Of Diacyl Bacterial Lipopeptide
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Nitric Oxide Metabolic Process
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Negative Regulation Of Synapse Assembly
Response To Fatty Acid
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Cellular Response To Interferon-gamma
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Matrix Metallopeptidase Secretion
Activation Of MAPK Activity
Positive Regulation Of Cytokine-mediated Signaling Pathway
Adaptive Immune Response
Positive Regulation Of T-helper 1 Type Immune Response
Apoptotic Process
Inflammatory Response
Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Cell Death
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Protein Binding
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Immature T Cell Proliferation
Positive Regulation Of Peptidyl-serine Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
T Cell Proliferation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-positive Bacterium
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-12
Response To Interleukin-18
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Xenophagy
Pathways
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Modulation by Mtb of host immune system
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
Downstream TCR signaling
p75NTR recruits signalling complexes
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
Drugs
Lyme disease vaccine (recombinant OspA)
Adapalene
S-(Dimethylarsenic)Cysteine
Golotimod
Tuberculin purified protein derivative
Fostamatinib
Diseases
GWAS
Body fat mass (
28552196
)
Cerebral amyloid deposition (PET imaging) (
26252872
)
Cognitive performance (
20125193
)
Crohn's disease (
23128233
)
Leprosy (
20018961
27976721
25642632
)
Interacting Genes
29 interacting genes:
AKT1
ANP32B
CD14
EGFR
FBP1
HEMGN
HMGB1
HRAS
HSP90B1
IRAK1
LY96
MAP2K1
MAPK8IP3
MYD88
NANS
PIK3R1
RAC1
RIPK2
SMAD1
STX17
TGFB1
TICAM1
TIRAP
TLR1
TLR10
TLR6
TMOD1
TOLLIP
TRIP6
32 interacting genes:
BCL10
BIRC2
BIRC3
CARD16
CARD6
CASP1
CASP8
CD40
CFLAR
CHUK
IKBKG
IRAK1
KDM3A
LRRK2
MAVS
NGFR
NOD1
NOD2
PELI3
PRMT2
SMAD4
SMURF1
TLR2
TLR4
TNFRSF1A
TRAF1
TRAF2
TRAF5
TRAF6
UBE2I
XIAP
ZNRF4
Entrez ID
7097
8767
HPRD ID
04323
04585
Ensembl ID
ENSG00000137462
ENSG00000104312
Uniprot IDs
A0A0S2Z4S4
B3KWR9
O60603
A0A0S2Z4Z8
O43353
PDB IDs
1FYW
1FYX
1O77
2Z7X
2Z80
6NIG
2N7Z
2N83
4C8B
5AR2
5AR3
5AR4
5AR5
5AR7
5AR8
5J79
5J7B
5NG0
5NG2
5NG3
5W5J
5W5O
5YRN
6ES0
6FU5
6GFJ
6GGS
6HMX
6RN8
6RNA
6S1F
6SZE
6SZJ
6UL8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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