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TLR2 and HMGB1
Data Source:
HPRD
(in vitro, in vivo)
TLR2
HMGB1
Description
toll like receptor 2
high mobility group box 1
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Intrinsic Component Of Plasma Membrane
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Cell Projection
Cell Body
Membrane Raft
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Early Endosome
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cell Surface
Transcription Repressor Complex
Secretory Granule Lumen
Alphav-beta3 Integrin-HMGB1 Complex
Neuron Projection
Ficolin-1-rich Granule Lumen
Molecular Function
Lipopolysaccharide Binding
Amyloid-beta Binding
Lipopolysaccharide Immune Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor Binding
Signaling Receptor Activity
Pattern Recognition Receptor Activity
Triacyl Lipopeptide Binding
Identical Protein Binding
Peptidoglycan Binding
Protein-containing Complex Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Four-way Junction DNA Binding
Bubble DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Lipopolysaccharide Binding
Phosphatidylserine Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Cytokine Activity
Integrin Binding
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Calcium-dependent Protein Kinase Regulator Activity
Lyase Activity
C-X-C Chemokine Binding
Protein Kinase Activator Activity
Chemoattractant Activity
RAGE Receptor Binding
DNA Polymerase Binding
Repressing Transcription Factor Binding
Supercoiled DNA Binding
Biological Process
Response To Hypoxia
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Leukotriene Metabolic Process
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
I-kappaB Phosphorylation
Learning
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Positive Regulation Of Gene Expression
Microglia Development
Positive Regulation Of Wnt Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Central Nervous System Myelin Formation
Response To Progesterone
Interleukin-10 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Insulin
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Triacyl Bacterial Lipopeptide
Detection Of Diacyl Bacterial Lipopeptide
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Nitric Oxide Metabolic Process
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Negative Regulation Of Synapse Assembly
Response To Fatty Acid
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Cellular Response To Interferon-gamma
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Matrix Metallopeptidase Secretion
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Myeloid Dendritic Cell Activation
Endothelial Cell Proliferation
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Plasmacytoid Dendritic Cell Activation
Macrophage Activation Involved In Immune Response
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
Regulation Of Tolerance Induction
Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA Topological Change
Base-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Apoptotic DNA Fragmentation
DNA Recombination
Chromatin Silencing
Regulation Of Transcription By RNA Polymerase II
Autophagy
Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Autophagy
Viral Process
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Lung Development
Neuron Projection Development
Chromatin Assembly
Regulation Of Restriction Endodeoxyribonuclease Activity
Activation Of Protein Kinase Activity
DNA Geometric Change
Positive Regulation Of Mismatch Repair
Tumor Necrosis Factor Production
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
V(D)J Recombination
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
T-helper 1 Cell Activation
Endothelial Cell Chemotaxis
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Glycogen Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Chemotaxis
Positive Regulation Of DNA Ligation
Response To Glucocorticoid
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Wound Healing
Neutrophil Clearance
Cellular Response To Interleukin-7
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Apoptotic Cell Clearance
Regulation Of Nucleotide-excision Repair
Positive Regulation Of Dendritic Cell Differentiation
Pathways
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Modulation by Mtb of host immune system
Apoptosis induced DNA fragmentation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Drugs
Lyme disease vaccine (recombinant OspA)
Adapalene
S-(Dimethylarsenic)Cysteine
Golotimod
Tuberculin purified protein derivative
Chloroquine
Ethyl pyruvate
Diseases
GWAS
Body fat mass (
28552196
)
Adult body size (
32376654
)
Apolipoprotein A1 levels (
32203549
)
Blood osmolality (transformed sodium) (
28360221
)
Carotid plaque burden (
28282560
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Hippocampal volume (
21116278
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Red blood cell count (
32888494
)
Triglyceride levels (
32203549
32154731
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
29 interacting genes:
AKT1
ANP32B
CD14
EGFR
FBP1
HEMGN
HMGB1
HRAS
HSP90B1
IRAK1
LY96
MAP2K1
MAPK8IP3
MYD88
NANS
PIK3R1
RAC1
RIPK2
SMAD1
STX17
TGFB1
TICAM1
TIRAP
TLR1
TLR10
TLR6
TMOD1
TOLLIP
TRIP6
96 interacting genes:
ACBD3
AGER
AGTRAP
AR
ATOH1
C1QBP
C3
CASP3
CCAR1
CCNDBP1
CDK1
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CTNNBL1
CUX1
DNM2
DNMT1
DUX4
EIF1
ENAH
EP300
ERF
ERG28
FIP1L1
FOXA3
FOXC1
GTF2A1
HES1
HMGA1
HNRNPK
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HPF1
HR
HSPA5
IRF2
KRT7
LRIF1
MECP2
MNT
MT2A
NCAN
NEUROD6
NEXN
NFKB1
NR3C1
PCOLCE
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PTPRZ1
RAD23B
RAG1
RASSF4
RB1
RBPJ
RELA
RFX1
RPL29
RPS12
RPS20
SIX5
SOX18
SPINT1
TAF1
TBP
TERF2
TERF2IP
TFE3
TGIF1
TLE1
TLE2
TLE5
TLR2
TLR4
TP53
TP73
UBE2I
UNC119
ZFP36
ZNF24
ZNF428
Entrez ID
7097
3146
HPRD ID
04323
01228
Ensembl ID
ENSG00000137462
ENSG00000189403
Uniprot IDs
A0A0S2Z4S4
B3KWR9
O60603
A0A024RDR0
P09429
PDB IDs
1FYW
1FYX
1O77
2Z7X
2Z80
6NIG
2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
6OEM
6OEN
6OEO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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