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TLR2 and TLR6
Data Source:
HPRD
(in vivo)
TLR2
TLR6
Description
toll like receptor 2
toll like receptor 6
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Intrinsic Component Of Plasma Membrane
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Cell Projection
Cell Body
Membrane Raft
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Phagocytic Vesicle Membrane
Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex
Receptor Complex
Membrane Raft
Molecular Function
Lipopolysaccharide Binding
Amyloid-beta Binding
Lipopolysaccharide Immune Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor Binding
Signaling Receptor Activity
Pattern Recognition Receptor Activity
Triacyl Lipopeptide Binding
Identical Protein Binding
Peptidoglycan Binding
Protein-containing Complex Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Amyloid-beta Binding
Transmembrane Signaling Receptor Activity
Signaling Receptor Binding
Protein Binding
Toll-like Receptor 2 Binding
Signaling Receptor Activity
Identical Protein Binding
Protein Heterodimerization Activity
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Lipopeptide Binding
Biological Process
Response To Hypoxia
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Leukotriene Metabolic Process
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
I-kappaB Phosphorylation
Learning
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Positive Regulation Of Gene Expression
Microglia Development
Positive Regulation Of Wnt Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Central Nervous System Myelin Formation
Response To Progesterone
Interleukin-10 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Insulin
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Triacyl Bacterial Lipopeptide
Detection Of Diacyl Bacterial Lipopeptide
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Nitric Oxide Metabolic Process
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Negative Regulation Of Synapse Assembly
Response To Fatty Acid
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Cellular Response To Interferon-gamma
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Matrix Metallopeptidase Secretion
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Immune Response
Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Positive Regulation Of Gene Expression
Interleukin-1 Beta Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Interleukin-6 Production
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 6 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Diacyl Bacterial Lipopeptide
Defense Response To Bacterium
Positive Regulation Of Macrophage Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Nitric Oxide Metabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Bacterial Lipopeptide
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Pathways
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Modulation by Mtb of host immune system
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Drugs
Lyme disease vaccine (recombinant OspA)
Adapalene
S-(Dimethylarsenic)Cysteine
Golotimod
Tuberculin purified protein derivative
Diseases
GWAS
Body fat mass (
28552196
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Allergic sensitization (
30013184
23817571
)
Allergy (
27182965
)
Asthma (
31959851
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) (
27670767
)
Helicobacter pylori serologic status (
23652523
)
Self-reported allergy (
23817569
)
Interacting Genes
29 interacting genes:
AKT1
ANP32B
CD14
EGFR
FBP1
HEMGN
HMGB1
HRAS
HSP90B1
IRAK1
LY96
MAP2K1
MAPK8IP3
MYD88
NANS
PIK3R1
RAC1
RIPK2
SMAD1
STX17
TGFB1
TICAM1
TIRAP
TLR1
TLR10
TLR6
TMOD1
TOLLIP
TRIP6
4 interacting genes:
BTK
HRAS
TLR2
TRAP1
Entrez ID
7097
10333
HPRD ID
04323
05656
Ensembl ID
ENSG00000137462
ENSG00000174130
Uniprot IDs
A0A0S2Z4S4
B3KWR9
O60603
B2R933
Q9Y2C9
PDB IDs
1FYW
1FYX
1O77
2Z7X
2Z80
6NIG
4OM7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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