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TLR2 and TLR1
Data Source:
HPRD
(in vivo)
TLR2
TLR1
Description
toll like receptor 2
toll like receptor 1
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Intrinsic Component Of Plasma Membrane
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Cell Projection
Cell Body
Membrane Raft
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Phagocytic Vesicle Membrane
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Membrane Raft
Molecular Function
Lipopolysaccharide Binding
Amyloid-beta Binding
Lipopolysaccharide Immune Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor Binding
Signaling Receptor Activity
Pattern Recognition Receptor Activity
Triacyl Lipopeptide Binding
Identical Protein Binding
Peptidoglycan Binding
Protein-containing Complex Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor 2 Binding
Signaling Receptor Activity
Identical Protein Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Lipopeptide Binding
Biological Process
Response To Hypoxia
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Leukotriene Metabolic Process
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
I-kappaB Phosphorylation
Learning
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Positive Regulation Of Gene Expression
Microglia Development
Positive Regulation Of Wnt Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Central Nervous System Myelin Formation
Response To Progesterone
Interleukin-10 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Insulin
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Triacyl Bacterial Lipopeptide
Detection Of Diacyl Bacterial Lipopeptide
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Nitric Oxide Metabolic Process
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Negative Regulation Of Synapse Assembly
Response To Fatty Acid
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Cellular Response To Interferon-gamma
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Matrix Metallopeptidase Secretion
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Immune Response
Signal Transduction
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 1 Signaling Pathway
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Macrophage Activation
Detection Of Triacyl Bacterial Lipopeptide
Innate Immune Response
Cellular Response To Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Pathways
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Modulation by Mtb of host immune system
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Drugs
Lyme disease vaccine (recombinant OspA)
Adapalene
S-(Dimethylarsenic)Cysteine
Golotimod
Tuberculin purified protein derivative
Diseases
GWAS
Body fat mass (
28552196
)
Alcohol consumption (
23743675
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
30013184
31361310
)
Allergic sensitization (
30013184
23817571
)
Allergy (
27182965
)
Asthma (
31361310
31959851
30929738
27182965
32296059
31619474
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma and hay fever (
24388013
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) (
27670767
)
Helicobacter pylori serologic status (
23652523
)
Self-reported allergy (
23817569
)
Systemic sclerosis (anti-topoisomerase-positive) (
29293537
)
Interacting Genes
29 interacting genes:
AKT1
ANP32B
CD14
EGFR
FBP1
HEMGN
HMGB1
HRAS
HSP90B1
IRAK1
LY96
MAP2K1
MAPK8IP3
MYD88
NANS
PIK3R1
RAC1
RIPK2
SMAD1
STX17
TGFB1
TICAM1
TIRAP
TLR1
TLR10
TLR6
TMOD1
TOLLIP
TRIP6
9 interacting genes:
DHX36
HSP90B1
HSPD1
TLR10
TLR2
TLR4
TLR5
TLR9
TRAP1
Entrez ID
7097
7096
HPRD ID
04323
03119
Ensembl ID
ENSG00000137462
ENSG00000174125
Uniprot IDs
A0A0S2Z4S4
B3KWR9
O60603
Q15399
PDB IDs
1FYW
1FYX
1O77
2Z7X
2Z80
6NIG
1FYV
2Z7X
6NIH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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