THOP1 and EPN2

Data Source:
BioGRID (two hybrid)

		THOP1	EPN2
Description		thimet oligopeptidase 1	epsin 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Intermembrane Space Cytosol	Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptide Binding Metal Ion Binding	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding
	Biological Process	Protein Polyubiquitination Proteolysis Peptide Metabolic Process	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 32888494) Plateletcrit ( 32888494) Total cholesterol levels ( 28334899)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547)
Interacting Genes		9 interacting genes: AGTR1 CALM1 EPN2 LINC01554 MPHOSPH6 PALS2 PRKACA STK11 TRAF2	40 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 SMAD1 SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG
Entrez ID		7064	22905
HPRD ID		03072	06271
Ensembl ID		ENSG00000172009	ENSG00000072134
Uniprot IDs		P52888	O95208
PDB IDs		1S4B 2O36
Enriched GO Terms of Interacting Partners?
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