THOP1 and MPHOSPH6

Data Source:
HPRD (two hybrid)

		THOP1	MPHOSPH6
Description		thimet oligopeptidase 1	M-phase phosphoprotein 6
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GO Annotations	Cellular Component	Mitochondrial Intermembrane Space Cytosol	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptide Binding Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	Protein Polyubiquitination Proteolysis Peptide Metabolic Process	Maturation Of 5.8S RRNA RRNA Processing
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 32888494) Plateletcrit ( 32888494) Total cholesterol levels ( 28334899)	Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)
Interacting Genes		9 interacting genes: AGTR1 CALM1 EPN2 LINC01554 MPHOSPH6 PALS2 PRKACA STK11 TRAF2	32 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		7064	10200
HPRD ID		03072	16111
Ensembl ID		ENSG00000172009	ENSG00000135698
Uniprot IDs		P52888	H3BNT4 Q99547
PDB IDs		1S4B 2O36	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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