RAD1 and RAD17

Data Source:
HPRD (in vivo, in vitro)

		RAD1	RAD17
Description		RAD1 checkpoint DNA exonuclease	RAD17 checkpoint clamp loader component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex Intracellular Membrane-bounded Organelle	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Rad17 RFC-like Complex
	Molecular Function	Damaged DNA Binding Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity	Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Substantia Nigra Development Meiotic Recombination Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Regulation Of Phosphorylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN	15 interacting genes: ATM ATR HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SNU13 USP20
Entrez ID		5810	5884
HPRD ID		04400	09124
Ensembl ID		ENSG00000113456	ENSG00000152942
Uniprot IDs		A0A024R045 O60671	O75943
PDB IDs		3A1J 3G65 3GGR 6J8Y
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?